GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor.
Bottom Line: GATA4 status was significantly associated with nuclear grade and van Nuys classification in DCIS and was positively associated with distant metastasis, histological grade and HER2 status, but negatively correlated with progesterone receptor labeling index in IDC.Subsequent multivariate analysis demonstrated that GATA4 status was an independent prognostic factor for both disease-free and breast cancer-specific survival of IDC patients.All of these results indicate that GATA4 plays important roles in the progression of breast carcinoma from an early stage and that immunohistochemical GATA4 status is considered a potent prognostic factor in human breast cancer patients.
Affiliation: Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.Show MeSH
Related in: MedlinePlus
Mentions: GATA4 immunoreactivity was detected in the nuclei of carcinoma cells in both DCIS (Fig.2a) and IDC (Fig.2b) tissues, but was negative in non-neoplastic mammary glands and stroma (Fig.2c). In the positive control, GATA4 was immunolocalized in the ovarian antral follicle (Fig.2d), as reported previously.21 When we immunolocalized GATA4 in 17 IDC cases using the microarray analysis, the median value of GATA4 signal intensity was 1.8-fold higher in GATA4-positive cases (n = 7) than GATA4-negative cases (n = 10), although the P-value did not reach significance (P = 0.071) (Fig.2e).
Affiliation: Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan.