Limits...
High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.

Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M, Usui Y, Goto H, Koyama T, Akiyama H, Miura O, Ogawa S, Arai A - Cancer Sci. (2014)

Bottom Line: Large CN loss in 6q was detected in three of four PIOL patients who had early CNS development and short survival periods, whereas long-term survivors did not have such deletions.The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage.They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Show MeSH

Related in: MedlinePlus

Intravitreal interleukin-10 (IL-10) levels in intraocular lymphomas (IOLs) with or without gain of the IL-10 gene. Data were analyzed for all patients (a), for primary IOL (PIOL) (b), and for IOL with a central nervous system lesion at diagnosis (IOCNSL) (c). The data represent the mean ± standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4317829&req=5

fig05: Intravitreal interleukin-10 (IL-10) levels in intraocular lymphomas (IOLs) with or without gain of the IL-10 gene. Data were analyzed for all patients (a), for primary IOL (PIOL) (b), and for IOL with a central nervous system lesion at diagnosis (IOCNSL) (c). The data represent the mean ± standard error of the mean.

Mentions: The most frequent gain regions of PIOLs and IOCNSLs were located on 1q. It is noteworthy that the 1q32.1 region located on 1q contained the genes for IL-10, a cytokine whose concentration in the vitreous fluid is significantly high in IOL. The CN of the IL-10 gene located on 1q32.1 was increased in 69% (11/16) of PIOLs, in 58% (7/12) of IOCNSL, in 80% (4/5) of SIOLs, and in 67% (22/33) in total. In order to examine the relation between CN change and IL-10 concentration, we compared the intravitreal IL-10 concentration of IL-10 gain-positive patients to that of IL-10 gain-negative patients. As shown in Figure5(a), the IL-10 concentration of the gain-positive patients was significantly higher than that of the gain-negative patients in all IOLs. However, we could not find a significant difference between them in each IOL subtype (Fig.5b,c), probably due to the small number of samples.


High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.

Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M, Usui Y, Goto H, Koyama T, Akiyama H, Miura O, Ogawa S, Arai A - Cancer Sci. (2014)

Intravitreal interleukin-10 (IL-10) levels in intraocular lymphomas (IOLs) with or without gain of the IL-10 gene. Data were analyzed for all patients (a), for primary IOL (PIOL) (b), and for IOL with a central nervous system lesion at diagnosis (IOCNSL) (c). The data represent the mean ± standard error of the mean.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317829&req=5

fig05: Intravitreal interleukin-10 (IL-10) levels in intraocular lymphomas (IOLs) with or without gain of the IL-10 gene. Data were analyzed for all patients (a), for primary IOL (PIOL) (b), and for IOL with a central nervous system lesion at diagnosis (IOCNSL) (c). The data represent the mean ± standard error of the mean.
Mentions: The most frequent gain regions of PIOLs and IOCNSLs were located on 1q. It is noteworthy that the 1q32.1 region located on 1q contained the genes for IL-10, a cytokine whose concentration in the vitreous fluid is significantly high in IOL. The CN of the IL-10 gene located on 1q32.1 was increased in 69% (11/16) of PIOLs, in 58% (7/12) of IOCNSL, in 80% (4/5) of SIOLs, and in 67% (22/33) in total. In order to examine the relation between CN change and IL-10 concentration, we compared the intravitreal IL-10 concentration of IL-10 gain-positive patients to that of IL-10 gain-negative patients. As shown in Figure5(a), the IL-10 concentration of the gain-positive patients was significantly higher than that of the gain-negative patients in all IOLs. However, we could not find a significant difference between them in each IOL subtype (Fig.5b,c), probably due to the small number of samples.

Bottom Line: Large CN loss in 6q was detected in three of four PIOL patients who had early CNS development and short survival periods, whereas long-term survivors did not have such deletions.The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage.They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus