High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.
Bottom Line: Large CN loss in 6q was detected in three of four PIOL patients who had early CNS development and short survival periods, whereas long-term survivors did not have such deletions.The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage.They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified.
Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.Show MeSH
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Mentions: The most frequent gain regions of PIOLs and IOCNSLs were located on 1q. It is noteworthy that the 1q32.1 region located on 1q contained the genes for IL-10, a cytokine whose concentration in the vitreous fluid is significantly high in IOL. The CN of the IL-10 gene located on 1q32.1 was increased in 69% (11/16) of PIOLs, in 58% (7/12) of IOCNSL, in 80% (4/5) of SIOLs, and in 67% (22/33) in total. In order to examine the relation between CN change and IL-10 concentration, we compared the intravitreal IL-10 concentration of IL-10 gain-positive patients to that of IL-10 gain-negative patients. As shown in Figure5(a), the IL-10 concentration of the gain-positive patients was significantly higher than that of the gain-negative patients in all IOLs. However, we could not find a significant difference between them in each IOL subtype (Fig.5b,c), probably due to the small number of samples.
Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.