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High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.

Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M, Usui Y, Goto H, Koyama T, Akiyama H, Miura O, Ogawa S, Arai A - Cancer Sci. (2014)

Bottom Line: Large CN loss in 6q was detected in three of four PIOL patients who had early CNS development and short survival periods, whereas long-term survivors did not have such deletions.The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage.They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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Copy number (CN) change is summarized in each type of intraocular lymphoma (IOL). Frequency of CN gains (a) and losses (b), as well as CN neutral loss of heterozygosity (c) involving >3 Mb segments were calculated and plotted for each IOL type. *Copy number changes detected in >20% of diffuse large B-cell lymphomas; **CN changes detected in >20% of follicular lymphomas; ***CN changes detected in >20% of mucosa-associated lymphoid tissue lymphomas; ****CN changes detected in >20% of mantle cell lymphomas. Black arrows indicate common frequent (>50%) gain regions in primary IOL (PIOL), and in IOL with a central nervous system lesion at diagnosis (IOCNSL). SIOL, secondary IOL.
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fig02: Copy number (CN) change is summarized in each type of intraocular lymphoma (IOL). Frequency of CN gains (a) and losses (b), as well as CN neutral loss of heterozygosity (c) involving >3 Mb segments were calculated and plotted for each IOL type. *Copy number changes detected in >20% of diffuse large B-cell lymphomas; **CN changes detected in >20% of follicular lymphomas; ***CN changes detected in >20% of mucosa-associated lymphoid tissue lymphomas; ****CN changes detected in >20% of mantle cell lymphomas. Black arrows indicate common frequent (>50%) gain regions in primary IOL (PIOL), and in IOL with a central nervous system lesion at diagnosis (IOCNSL). SIOL, secondary IOL.

Mentions: Copy number (CN) changes of all IOL samples are shown in Figures1 and 2. As in our previous report, we defined CN changes as CN gains, losses, as well as neutral loss of heterozygosity involving >3 Mb segments (Fig.2). As shown in Figures1 and 2(a), the most frequent CN gain region in PIOL was 1q, detected in 81% (13/16) of cases, followed by 18q and 19q in 69% (11/16), 12q in 63% (10/16), 7q and 11q in 56% (9/16), and 3q, 10q, and 19p in 50% (8/16). As shown in Figures1 and 2(b,c), the most frequent CN loss in PIOLs was on 6q (44%, 7/16), whereas uniparental disomy was detected on various regions in only patient.


High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays.

Wang L, Sato-Otsubo A, Sugita S, Takase H, Mochizuki M, Usui Y, Goto H, Koyama T, Akiyama H, Miura O, Ogawa S, Arai A - Cancer Sci. (2014)

Copy number (CN) change is summarized in each type of intraocular lymphoma (IOL). Frequency of CN gains (a) and losses (b), as well as CN neutral loss of heterozygosity (c) involving >3 Mb segments were calculated and plotted for each IOL type. *Copy number changes detected in >20% of diffuse large B-cell lymphomas; **CN changes detected in >20% of follicular lymphomas; ***CN changes detected in >20% of mucosa-associated lymphoid tissue lymphomas; ****CN changes detected in >20% of mantle cell lymphomas. Black arrows indicate common frequent (>50%) gain regions in primary IOL (PIOL), and in IOL with a central nervous system lesion at diagnosis (IOCNSL). SIOL, secondary IOL.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317829&req=5

fig02: Copy number (CN) change is summarized in each type of intraocular lymphoma (IOL). Frequency of CN gains (a) and losses (b), as well as CN neutral loss of heterozygosity (c) involving >3 Mb segments were calculated and plotted for each IOL type. *Copy number changes detected in >20% of diffuse large B-cell lymphomas; **CN changes detected in >20% of follicular lymphomas; ***CN changes detected in >20% of mucosa-associated lymphoid tissue lymphomas; ****CN changes detected in >20% of mantle cell lymphomas. Black arrows indicate common frequent (>50%) gain regions in primary IOL (PIOL), and in IOL with a central nervous system lesion at diagnosis (IOCNSL). SIOL, secondary IOL.
Mentions: Copy number (CN) changes of all IOL samples are shown in Figures1 and 2. As in our previous report, we defined CN changes as CN gains, losses, as well as neutral loss of heterozygosity involving >3 Mb segments (Fig.2). As shown in Figures1 and 2(a), the most frequent CN gain region in PIOL was 1q, detected in 81% (13/16) of cases, followed by 18q and 19q in 69% (11/16), 12q in 63% (10/16), 7q and 11q in 56% (9/16), and 3q, 10q, and 19p in 50% (8/16). As shown in Figures1 and 2(b,c), the most frequent CN loss in PIOLs was on 6q (44%, 7/16), whereas uniparental disomy was detected on various regions in only patient.

Bottom Line: Large CN loss in 6q was detected in three of four PIOL patients who had early CNS development and short survival periods, whereas long-term survivors did not have such deletions.The results suggest that IOCNSL is a highly malignant form of PIOL that infiltrates into the CNS at an early stage.They also indicate that genetic differences between PIOL and primary CNS lymphoma need to be clarified.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Show MeSH
Related in: MedlinePlus