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Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.

Huang XM, Liu XS, Lin XK, Yu H, Sun JY, Liu XK, Chen C, Jin HL, Zhang GE, Shi XX, Zhang Q, Yu JR - Cancer Sci. (2014)

Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.

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Related in: MedlinePlus

Cytokine levels in blood and tissue in patients with gastric cancer. (a) Representative example of Western blotting for interleukin (IL)-10 and transforming growth factor-β (TGF-β1) is shown. The concentration of IL-10 decreased with decreased distance from the cancer site. The concentration of TGF-β1 in normal tissue was lower than tumor tissue and peritumor tissue. (b) Plasma levels of both IL-10 and IL-2 were higher in patients with GC than in control subjects
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fig06: Cytokine levels in blood and tissue in patients with gastric cancer. (a) Representative example of Western blotting for interleukin (IL)-10 and transforming growth factor-β (TGF-β1) is shown. The concentration of IL-10 decreased with decreased distance from the cancer site. The concentration of TGF-β1 in normal tissue was lower than tumor tissue and peritumor tissue. (b) Plasma levels of both IL-10 and IL-2 were higher in patients with GC than in control subjects

Mentions: To study the changes in the concentrations of cytokines in gastric tissue, we first analyzed frozen tissue by Western blotting. As shown in Figure 6(a), the concentration of IL-10 was highest in the carcinoma tissue, followed by peritumor tissue, and lowest in normal tissue. Normal tissue had a lower concentration of TGF-β1 than tumor tissue and peritumor tissue, their levels in tumor tissue and peritumor tissue were similar.


Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.

Huang XM, Liu XS, Lin XK, Yu H, Sun JY, Liu XK, Chen C, Jin HL, Zhang GE, Shi XX, Zhang Q, Yu JR - Cancer Sci. (2014)

Cytokine levels in blood and tissue in patients with gastric cancer. (a) Representative example of Western blotting for interleukin (IL)-10 and transforming growth factor-β (TGF-β1) is shown. The concentration of IL-10 decreased with decreased distance from the cancer site. The concentration of TGF-β1 in normal tissue was lower than tumor tissue and peritumor tissue. (b) Plasma levels of both IL-10 and IL-2 were higher in patients with GC than in control subjects
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317822&req=5

fig06: Cytokine levels in blood and tissue in patients with gastric cancer. (a) Representative example of Western blotting for interleukin (IL)-10 and transforming growth factor-β (TGF-β1) is shown. The concentration of IL-10 decreased with decreased distance from the cancer site. The concentration of TGF-β1 in normal tissue was lower than tumor tissue and peritumor tissue. (b) Plasma levels of both IL-10 and IL-2 were higher in patients with GC than in control subjects
Mentions: To study the changes in the concentrations of cytokines in gastric tissue, we first analyzed frozen tissue by Western blotting. As shown in Figure 6(a), the concentration of IL-10 was highest in the carcinoma tissue, followed by peritumor tissue, and lowest in normal tissue. Normal tissue had a lower concentration of TGF-β1 than tumor tissue and peritumor tissue, their levels in tumor tissue and peritumor tissue were similar.

Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.

Show MeSH
Related in: MedlinePlus