Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.
Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.Show MeSH
Related in: MedlinePlus
Mentions: To study the changes in the concentrations of cytokines in gastric tissue, we first analyzed frozen tissue by Western blotting. As shown in Figure 6(a), the concentration of IL-10 was highest in the carcinoma tissue, followed by peritumor tissue, and lowest in normal tissue. Normal tissue had a lower concentration of TGF-β1 than tumor tissue and peritumor tissue, their levels in tumor tissue and peritumor tissue were similar.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.