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Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.

Huang XM, Liu XS, Lin XK, Yu H, Sun JY, Liu XK, Chen C, Jin HL, Zhang GE, Shi XX, Zhang Q, Yu JR - Cancer Sci. (2014)

Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.

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Related in: MedlinePlus

Distribution of blood dendritic cell antigen 2 (BDCA2)+ plasmacytoid dendritic cells (pDCs). (a) Representative immunohistochemical staining of BDCA-2 in frozen sections. Positive cells in tumor, peritumor, and normal gastric tissue are showing a plasmacytoid, roundish morphology with dendritic processes (black arrow) (magnification, ×400). (b) Distribution of BDCA2+ pDCs in peritumor tissue was higher than that in cancer tissue or normal tissue. (c) A positive correlation between pDCs and inducible costimulator (ICOS)+ regulatory T cells (Tregs) was observed in peritumor tissue.
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fig04: Distribution of blood dendritic cell antigen 2 (BDCA2)+ plasmacytoid dendritic cells (pDCs). (a) Representative immunohistochemical staining of BDCA-2 in frozen sections. Positive cells in tumor, peritumor, and normal gastric tissue are showing a plasmacytoid, roundish morphology with dendritic processes (black arrow) (magnification, ×400). (b) Distribution of BDCA2+ pDCs in peritumor tissue was higher than that in cancer tissue or normal tissue. (c) A positive correlation between pDCs and inducible costimulator (ICOS)+ regulatory T cells (Tregs) was observed in peritumor tissue.

Mentions: Immunohistochemical staining of BDCA-2 revealed that pDCs were present in stomach tissues of GC patients. Strikingly, the number of pDCs in peritumor tissue (0.60 [range, 0.00–4.90]) was higher than that in cancer tissue (0.30 [range, 0.00–4.20], P = 0.054]) or normal tissue (0.30 [range, 0.00–3.50], P = 0.01) (Fig. 4a,b).


Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.

Huang XM, Liu XS, Lin XK, Yu H, Sun JY, Liu XK, Chen C, Jin HL, Zhang GE, Shi XX, Zhang Q, Yu JR - Cancer Sci. (2014)

Distribution of blood dendritic cell antigen 2 (BDCA2)+ plasmacytoid dendritic cells (pDCs). (a) Representative immunohistochemical staining of BDCA-2 in frozen sections. Positive cells in tumor, peritumor, and normal gastric tissue are showing a plasmacytoid, roundish morphology with dendritic processes (black arrow) (magnification, ×400). (b) Distribution of BDCA2+ pDCs in peritumor tissue was higher than that in cancer tissue or normal tissue. (c) A positive correlation between pDCs and inducible costimulator (ICOS)+ regulatory T cells (Tregs) was observed in peritumor tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317822&req=5

fig04: Distribution of blood dendritic cell antigen 2 (BDCA2)+ plasmacytoid dendritic cells (pDCs). (a) Representative immunohistochemical staining of BDCA-2 in frozen sections. Positive cells in tumor, peritumor, and normal gastric tissue are showing a plasmacytoid, roundish morphology with dendritic processes (black arrow) (magnification, ×400). (b) Distribution of BDCA2+ pDCs in peritumor tissue was higher than that in cancer tissue or normal tissue. (c) A positive correlation between pDCs and inducible costimulator (ICOS)+ regulatory T cells (Tregs) was observed in peritumor tissue.
Mentions: Immunohistochemical staining of BDCA-2 revealed that pDCs were present in stomach tissues of GC patients. Strikingly, the number of pDCs in peritumor tissue (0.60 [range, 0.00–4.90]) was higher than that in cancer tissue (0.30 [range, 0.00–4.20], P = 0.054]) or normal tissue (0.30 [range, 0.00–3.50], P = 0.01) (Fig. 4a,b).

Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.

Show MeSH
Related in: MedlinePlus