Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.
Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.Show MeSH
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Mentions: Plasmacytoid dendritic cells were identified as Lin−HLA-DR+CD11c−CD123high cells (Fig. 3a). The proportion of circulating pDCs among Lineage− cells was significantly higher in GC patients than in control donors (2.64% [range, 0.14–10.70%] vs 1.51% [range, 0.11–6.91%], P = 0.027; Fig. 3b).
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.