Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer.
Bottom Line: We found that the numbers of pDCs, Tregs, and ICOS(+) Tregs in peripheral blood were increased in GC patients compared with healthy donors.In tissue, Tregs and ICOS(+) Tregs were found distributing mainly in carcinoma tissue, whereas pDCs were mainly found in peritumor tissue.In conclusion, pDCs may play a potential role in recruiting ICOS(+) Tregs, and both participate in the immunosuppression microenvironment of GC.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.Show MeSH
Related in: MedlinePlus
Mentions: Circulating Tregs are defined as the population of CD4+CD25+Foxp3+ T cells as a percentage of CD4+ lymphocytes. There was an increased number of circulating Tregs in GC patients compared to the control group (4.69 ± 1.72% vs 3.38 ± 1.04%, P = 0.001; Fig. 1a,b). Moreover, the number of Foxp3+ T cells in tumor tissue (10.45 [range, 0.20–59.50]) are twice that in peritumor tissue (4.55 [range, 0.20–19.60], P = 0.001), and three times that in normal gastric mucosa (3.20 [range, 0.00–13.50], P = 0.001) (Fig. 2a,c). These results collectively suggest high enrichment of Tregs in GC patients.
Affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.