Clinical significance of macrophage heterogeneity in human malignant tumors.
Bottom Line: The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known.Based on recent basic and preclinical research, TAMs that have differentiated into protumoral or M2 macrophages are believed to be intimately involved in the angiogenesis, immunosuppression, and activation of tumor cells.In this paper, we specifically discuss both the role of TAMs in human malignant tumors and the cell-cell interactions between TAMs and tumor cells.
Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.Show MeSH
Related in: MedlinePlus
Mentions: The abovementioned experimental instruction was quite simple. Our experiments demanded only extraordinary patience for a period of years. The dried tar crust produced by the repeated tar painting was removed with the tweezers every time, so the epithelial plug and newly made or dilated capillaries were often disrupted, and small amounts of bleeding and superficial tissue defect occurred. To avoid the boring repetition of the study, the main results will be presented later in the tables. (Note that a summary of the experiment series I–IV is in Table VI, and the representative figures of the experiments are Figs 6, 9, and 31.)
Affiliation: Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.