Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.
Bottom Line: BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation.There were no significant differences between the two groups with regard to clinical characteristics and outcomes.In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256).
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.Show MeSH
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Mentions: All cases were treated with rituximab-containing chemotherapy, and in two cases, intensive chemotherapy was performed, taking into consideration the poor prognosis of MYC+ DLBCL.(2,3) The MYC+ group showed poor prognosis; 3-year OS and PFS rates were 35.0% and 33.7%, respectively (Fig. 4).
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.