Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.
Bottom Line: BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation.There were no significant differences between the two groups with regard to clinical characteristics and outcomes.In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256).
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.Show MeSH
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Mentions: To elucidate the subgroups in which BACH2 can strongly predict the prognosis, we further analyzed the association between BACH2 expression levels and clinical outcome in various stratifications by log-rank analysis (Table 3 and Fig. 3). In any subgroups, a high level of BACH2 expression was associated with shorter survival time. In particular, a high level of BACH2 expression was a strong predictor of poor prognosis among the subgroups which had negative prognostic indicators such as higher serum LDH level, higher sIL-2R level and advanced clinical stage.
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.