Limits...
Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.

Ichikawa S, Fukuhara N, Katsushima H, Takahashi T, Yamamoto J, Yokoyama H, Sasaki O, Fukuhara O, Nomura J, Ishizawa K, Ichinohasama R, Muto A, Igarashi K, Harigae H - Cancer Sci. (2014)

Bottom Line: BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation.There were no significant differences between the two groups with regard to clinical characteristics and outcomes.In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256).

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Show MeSH

Related in: MedlinePlus

Representative figures of high and low BACH2 expression determined by immunohistochemistry. (a,b) A case with high level of BACH2 expression (a, at low-power magnification; b, at high-power magnification). Lymphoma cells are homogeneously stained for BACH2. Cytoplasmic staining is dominant. (c,d) A case with low level of BACH2 expression (c), at low-power magnification; (d) at high-power magnification). Lymphoma cells were slightly stained for BACH2 in cytoplasm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4317811&req=5

fig01: Representative figures of high and low BACH2 expression determined by immunohistochemistry. (a,b) A case with high level of BACH2 expression (a, at low-power magnification; b, at high-power magnification). Lymphoma cells are homogeneously stained for BACH2. Cytoplasmic staining is dominant. (c,d) A case with low level of BACH2 expression (c), at low-power magnification; (d) at high-power magnification). Lymphoma cells were slightly stained for BACH2 in cytoplasm.

Mentions: Representative immunohistochemical findings for BACH2 are shown in Figure 1. In all cases BACH2 is predominantly stained in cytoplasm. A total of 40 and 36 cases were subclassified into the high and low BACH2-expression groups, respectively (Table 1). The relationship between Hans' criteria and BACH2 expression, and the relationship between MUM1 and BACH2 expression, could not be detected. There were no significantly different features detected among the two groups, except that significantly more cases with high levels of BACH2-expression had high levels of MYC expression (Table 1).


Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.

Ichikawa S, Fukuhara N, Katsushima H, Takahashi T, Yamamoto J, Yokoyama H, Sasaki O, Fukuhara O, Nomura J, Ishizawa K, Ichinohasama R, Muto A, Igarashi K, Harigae H - Cancer Sci. (2014)

Representative figures of high and low BACH2 expression determined by immunohistochemistry. (a,b) A case with high level of BACH2 expression (a, at low-power magnification; b, at high-power magnification). Lymphoma cells are homogeneously stained for BACH2. Cytoplasmic staining is dominant. (c,d) A case with low level of BACH2 expression (c), at low-power magnification; (d) at high-power magnification). Lymphoma cells were slightly stained for BACH2 in cytoplasm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317811&req=5

fig01: Representative figures of high and low BACH2 expression determined by immunohistochemistry. (a,b) A case with high level of BACH2 expression (a, at low-power magnification; b, at high-power magnification). Lymphoma cells are homogeneously stained for BACH2. Cytoplasmic staining is dominant. (c,d) A case with low level of BACH2 expression (c), at low-power magnification; (d) at high-power magnification). Lymphoma cells were slightly stained for BACH2 in cytoplasm.
Mentions: Representative immunohistochemical findings for BACH2 are shown in Figure 1. In all cases BACH2 is predominantly stained in cytoplasm. A total of 40 and 36 cases were subclassified into the high and low BACH2-expression groups, respectively (Table 1). The relationship between Hans' criteria and BACH2 expression, and the relationship between MUM1 and BACH2 expression, could not be detected. There were no significantly different features detected among the two groups, except that significantly more cases with high levels of BACH2-expression had high levels of MYC expression (Table 1).

Bottom Line: BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation.There were no significant differences between the two groups with regard to clinical characteristics and outcomes.In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256).

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Show MeSH
Related in: MedlinePlus