Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma.
Bottom Line: BACH2, a B cell-specific transcriptional repressor, plays a significant role in B cell maturation.There were no significant differences between the two groups with regard to clinical characteristics and outcomes.In cases with high BACH2 expression in GCB and non-GCB groups, the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256).
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.Show MeSH
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Mentions: Representative immunohistochemical findings for BACH2 are shown in Figure 1. In all cases BACH2 is predominantly stained in cytoplasm. A total of 40 and 36 cases were subclassified into the high and low BACH2-expression groups, respectively (Table 1). The relationship between Hans' criteria and BACH2 expression, and the relationship between MUM1 and BACH2 expression, could not be detected. There were no significantly different features detected among the two groups, except that significantly more cases with high levels of BACH2-expression had high levels of MYC expression (Table 1).
Affiliation: Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.