Increased risk of cancer in patients with early-onset cataracts: a nationwide population-based study.
Bottom Line: Both cohorts were followed up until 2010 to estimate the incidences of cancer.We used the Poisson regression model to compare incidence rate ratios and the 95% confidence interval (CI).The site-specific analysis also showed a strong relationship, with adjusted HR of 3.24 ((95% CI = 1.30, 8.10) for head and neck cancer, 3.29 (95% CI 1.16, 9.31) for hepatoma and 3.19 (95% CI 1.34, 7.58) for breast cancer.
Affiliation: Division of Ophthalmology, China Medical University Hospital, Taichung, Taiwan; School of Medicine, China Medical University College of Medicine, Taichung, Taiwan.Show MeSH
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Mentions: Kaplan–Meier analysis showed that patients with early-onset cataracts had significantly higher cumulative incidence rates for all cancers than the comparison group (8.13 vs 3.90) by the end of the 12-year follow up, especially for head and neck cancer (1.07 vs 0.39%), hepatoma (1.25 vs 0.36%) and breast cancer (1.59 vs 0.39%) (Fig. 1).
Affiliation: Division of Ophthalmology, China Medical University Hospital, Taichung, Taiwan; School of Medicine, China Medical University College of Medicine, Taichung, Taiwan.