Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.
Bottom Line: Oropharyngeal carcinoma was more frequently HPV-positive than non-oropharyngeal carcinoma (34.4% vs 3.6%, P < 0.001), and HPV16 accounted for 91.1% of HPV-positive tumors.In oropharyngeal carcinoma, which showed an increasing trend of HPV prevalence over time (P < 0.001), HPV infection was inversely correlated with tobacco smoking, alcohol drinking, p53 mutations, and a disruptive mutation (P = 0.003, <0.001, <0.001, and <0.001, respectively).A disruptive mutation was never found in virus-related HNSCC, whereas it was independently associated with primary site, such as the oropharynx and hypopharynx (P = 0.01 and 0.03, respectively), in virus-unrelated HNSCC.
Affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Faculty of Medicine, Suita, Japan.Show MeSH
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Mentions: As HPV-positive tumors were specific to the palatine and lingual tonsils among subsites of the oropharynx, we addressed the chronological change of HPV prevalence in oropharyngeal carcinoma originating from these subsites. Prevalence of HPV was increased from 36.8% during 1995 to 1999, 39.0% during 2000 to 2009, to 48.3% during 2010 to 2012 (Fig. 1). This increasing trend across calendar periods was statistically significant (P < 0.001).
Affiliation: Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Faculty of Medicine, Suita, Japan.