Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.
Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.Show MeSH
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Mentions: Overall/progression-free survival rates were compared between the positive and negative expression of LC3, Beclin1 and p62/SQSTM1 in the central and peripheral areas. No significant differences were observed in survival by the log-rank test, except for shorter overall survival with the positive expression of LC3 in the peripheral area (P = 0.030), as shown in Figure3. We also examined the relationship between overall/progression-free survival rates and the number (divided into higher/lower groups by median) of CD1a+ dendritic cells, CD3+ T cells or CD56+ NK cells, as well as the expression of HLA class I/class II by the log-rank test; however, no correlations were detected among these parameters. Univariate regression analysis revealed that lymphatic invasion, vascular invasion, lymph node metastasis, an advanced clinical stage, recurrence and the peripheral expression of LC3 correlated with overall survival, while lymphatic invasion, lymph node metastasis, recurrence and a high Ki-67 labeling index correlated with progression-free survival, as indicated in Table7. Multivariate regression analysis revealed that vascular invasion, recurrence and the peripheral expression of LC3 correlated with overall survival, but not progression-free survival (Table7).
Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.