Limits...
Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.

Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K - Cancer Sci. (2014)

Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Show MeSH

Related in: MedlinePlus

Representative serial immunohistochemistry (IHC) pictures of the expressions of molecules which showed statistically significant association each other. (a) LC3 and p62/SQSTM1 significantly correlated with CD3+ T cell infiltration. (b) p62/SQSTM1 was closely related to the expression of HLA class I. (c) Beclin-1 was significantly related to HLA class II expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4317780&req=5

fig02: Representative serial immunohistochemistry (IHC) pictures of the expressions of molecules which showed statistically significant association each other. (a) LC3 and p62/SQSTM1 significantly correlated with CD3+ T cell infiltration. (b) p62/SQSTM1 was closely related to the expression of HLA class I. (c) Beclin-1 was significantly related to HLA class II expression.

Mentions: Table4 shows the relationships between the autophagy-related proteins LC3, Beclin-1 and p62/SQSTM1, and the immune infiltrates DC, T cells, NK cells and HLA molecules in the central and peripheral sites of cancer tissue (by Mann–Whitney's U-test and the Kruskal–Wallis test). Table5 describes the detailed IHC data of the statistically significant parameters. The peripheral expression of LC3 was correlated with the number of CD3+ T cells in the peripheral site (Fig.2a), but not in the central site of tumor, in which hypoxia and nutrient starvation was apparent. The expression of p62/SQSTM1 in the peripheral site was also related to the peripheral infiltration of CD+ T cells (Fig.2a). Strong correlations were observed between the expression of p62/SQSTM1 and HLA class I (Fig.2b), as well as HLA class II and Beclin-1 (Fig.2c). As described above, the expression of the three autophagy components appeared to be associated with immunologically favorable phenomena, especially in the peripheral site of the tumor.


Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.

Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K - Cancer Sci. (2014)

Representative serial immunohistochemistry (IHC) pictures of the expressions of molecules which showed statistically significant association each other. (a) LC3 and p62/SQSTM1 significantly correlated with CD3+ T cell infiltration. (b) p62/SQSTM1 was closely related to the expression of HLA class I. (c) Beclin-1 was significantly related to HLA class II expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317780&req=5

fig02: Representative serial immunohistochemistry (IHC) pictures of the expressions of molecules which showed statistically significant association each other. (a) LC3 and p62/SQSTM1 significantly correlated with CD3+ T cell infiltration. (b) p62/SQSTM1 was closely related to the expression of HLA class I. (c) Beclin-1 was significantly related to HLA class II expression.
Mentions: Table4 shows the relationships between the autophagy-related proteins LC3, Beclin-1 and p62/SQSTM1, and the immune infiltrates DC, T cells, NK cells and HLA molecules in the central and peripheral sites of cancer tissue (by Mann–Whitney's U-test and the Kruskal–Wallis test). Table5 describes the detailed IHC data of the statistically significant parameters. The peripheral expression of LC3 was correlated with the number of CD3+ T cells in the peripheral site (Fig.2a), but not in the central site of tumor, in which hypoxia and nutrient starvation was apparent. The expression of p62/SQSTM1 in the peripheral site was also related to the peripheral infiltration of CD+ T cells (Fig.2a). Strong correlations were observed between the expression of p62/SQSTM1 and HLA class I (Fig.2b), as well as HLA class II and Beclin-1 (Fig.2c). As described above, the expression of the three autophagy components appeared to be associated with immunologically favorable phenomena, especially in the peripheral site of the tumor.

Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Show MeSH
Related in: MedlinePlus