Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.
Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.Show MeSH
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Mentions: Table4 shows the relationships between the autophagy-related proteins LC3, Beclin-1 and p62/SQSTM1, and the immune infiltrates DC, T cells, NK cells and HLA molecules in the central and peripheral sites of cancer tissue (by Mann–Whitney's U-test and the Kruskal–Wallis test). Table5 describes the detailed IHC data of the statistically significant parameters. The peripheral expression of LC3 was correlated with the number of CD3+ T cells in the peripheral site (Fig.2a), but not in the central site of tumor, in which hypoxia and nutrient starvation was apparent. The expression of p62/SQSTM1 in the peripheral site was also related to the peripheral infiltration of CD+ T cells (Fig.2a). Strong correlations were observed between the expression of p62/SQSTM1 and HLA class I (Fig.2b), as well as HLA class II and Beclin-1 (Fig.2c). As described above, the expression of the three autophagy components appeared to be associated with immunologically favorable phenomena, especially in the peripheral site of the tumor.
Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.