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Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.

Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K - Cancer Sci. (2014)

Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

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Related in: MedlinePlus

(a) Representative immunohistochemistry (IHC) staining of LC3, Beclin-1 and p62 (×400 magnification), according to the intensity scores. All pictures were taken under the same photographic condition. LC3 and p62 SQSTM1 were expressed in puncta corresponding to autophagosomes in the cytoplasm. Beclin-1 was mainly expressed in the cytoplasm. (b) Representative CD1a+ DC, CD3+ T cell, CD56+ NK cell, HLA class I heavy chain and class II stainings were presented under magnification of ×400. HLA class I heavy chain and class II were presented as a membranous pattern.
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fig01: (a) Representative immunohistochemistry (IHC) staining of LC3, Beclin-1 and p62 (×400 magnification), according to the intensity scores. All pictures were taken under the same photographic condition. LC3 and p62 SQSTM1 were expressed in puncta corresponding to autophagosomes in the cytoplasm. Beclin-1 was mainly expressed in the cytoplasm. (b) Representative CD1a+ DC, CD3+ T cell, CD56+ NK cell, HLA class I heavy chain and class II stainings were presented under magnification of ×400. HLA class I heavy chain and class II were presented as a membranous pattern.

Mentions: Figure1(a) shows representative IHC staining of LC3, Beclin-1 and p62/SQSTM1, respectively, according to the scores for the staining intensity. LC3 and p62/SQSTM1 were expressed in puncta, corresponding to autophagosomes in the cytoplasm.26 Beclin-1 was mainly expressed in the cytoplasm. LC3, Beclin-1 and p62/SQSTM1 accumulated in 27 (36.5%), 27 (36.5%) and 24 (32.4%) of the 74 cases of OCCC examined, respectively. The detailed basic data of expressions of autophagy-related proteins are summarized in Table3. No significant differences were observed in the peripheral or central expression of these autophagy components.


Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.

Sakakura K, Takahashi H, Kaira K, Toyoda M, Oyama T, Chikamatsu K - Cancer Sci. (2014)

(a) Representative immunohistochemistry (IHC) staining of LC3, Beclin-1 and p62 (×400 magnification), according to the intensity scores. All pictures were taken under the same photographic condition. LC3 and p62 SQSTM1 were expressed in puncta corresponding to autophagosomes in the cytoplasm. Beclin-1 was mainly expressed in the cytoplasm. (b) Representative CD1a+ DC, CD3+ T cell, CD56+ NK cell, HLA class I heavy chain and class II stainings were presented under magnification of ×400. HLA class I heavy chain and class II were presented as a membranous pattern.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317780&req=5

fig01: (a) Representative immunohistochemistry (IHC) staining of LC3, Beclin-1 and p62 (×400 magnification), according to the intensity scores. All pictures were taken under the same photographic condition. LC3 and p62 SQSTM1 were expressed in puncta corresponding to autophagosomes in the cytoplasm. Beclin-1 was mainly expressed in the cytoplasm. (b) Representative CD1a+ DC, CD3+ T cell, CD56+ NK cell, HLA class I heavy chain and class II stainings were presented under magnification of ×400. HLA class I heavy chain and class II were presented as a membranous pattern.
Mentions: Figure1(a) shows representative IHC staining of LC3, Beclin-1 and p62/SQSTM1, respectively, according to the scores for the staining intensity. LC3 and p62/SQSTM1 were expressed in puncta, corresponding to autophagosomes in the cytoplasm.26 Beclin-1 was mainly expressed in the cytoplasm. LC3, Beclin-1 and p62/SQSTM1 accumulated in 27 (36.5%), 27 (36.5%) and 24 (32.4%) of the 74 cases of OCCC examined, respectively. The detailed basic data of expressions of autophagy-related proteins are summarized in Table3. No significant differences were observed in the peripheral or central expression of these autophagy components.

Bottom Line: The relationship between the expression of autophagy-associated molecules and various clinicopathological parameters was also evaluated.In addition, several unfavorable clinicopathological parameters correlated with an increase in the expression of LC3 in the peripheral site.Meanwhile, the three autophagy-associated proteins examined were linked to malignant potential and an unfavorable prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Otolaryngology - Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan.

Show MeSH
Related in: MedlinePlus