ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.
Bottom Line: Multivariate analyses demonstrated that good PS, invasive ductal carcinoma, non-triple negative phenotype and initial operable stage were significantly associated with a lower death risk.Our results also suggest that the prediction of docetaxel toxicity might be possible for C3435T polymorphism.This study results provides valuable information on individualized therapy according to genotypes.
Affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.Show MeSH
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Mentions: The ABCB1 3435TT genotype showed a higher AUCdoc than the CC/CT genotype with statistical significance (P = 0.031) (Fig.2). However, the ABCB1 G2677T/A or C1236T genotypes showed no association with AUCdoc or AUCdox. Among the genotypes of CYP3A5, AA (*1/*1)/AG (*1/*3) genotypes had a higher AUC of docetaxel than the GG (*3/*3) genotype with statistical significance (P = 0.024). The ABCB1 3435TT genotype was correlated with neutropenia (P = 0.039), febrile neutropenia (P = 0.218), and diarrhea (P = 0.057). CYP3A5 polymorphism did not affect survival and toxicities.
Affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.