ABCB1 polymorphism as prognostic factor in breast cancer patients treated with docetaxel and doxorubicin neoadjuvant chemotherapy.
Bottom Line: Multivariate analyses demonstrated that good PS, invasive ductal carcinoma, non-triple negative phenotype and initial operable stage were significantly associated with a lower death risk.Our results also suggest that the prediction of docetaxel toxicity might be possible for C3435T polymorphism.This study results provides valuable information on individualized therapy according to genotypes.
Affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.Show MeSH
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Mentions: The overall clinical response rate (RR) was 76.8%. Twenty patients (9.3%) achieved clinical complete response (cCR) and 18 (8.3%) achieved pCR. Among the PK group, RR was 82.0% with 4.2% of pCR. ABCB1 C3435T, G2677T/A, and C1236T SNPs did not predict the responders. As shown in Figure1, ABCB1 3435TT genotype had a longer OS than the CT/TT genotype with statistical significance (P = 0.024). A similar trend was observed for the RFS, that is, ABCB1 3435TT genotype tended to have a longer RFS although it was not statistically significant (P = 0.234). ABCB1 G2677T/A and C1236T were analyzed, and there were no significant differences in the RFS and OS (Fig. S1).
Affiliation: Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.