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Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type.

de Souza PS, Cruz AL, Viola JP, Maia RC - Cancer Sci. (2014)

Bottom Line: By co-culturing MP derived from MDR-positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA.In addition, MP promoted microRNA transfer and NFκB and Yb-1 activation.Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.

View Article: PubMed Central - PubMed

Affiliation: Program of Hemato-Oncology Molecular, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.

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Schematic diagram of multifactorial phenotype acquisition. Multidrug resistant (MDR) cancer cell-derived MP carry and transfer MDR molecules to non-resistant cancer cells, which can then establish multifactorial resistance.
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fig07: Schematic diagram of multifactorial phenotype acquisition. Multidrug resistant (MDR) cancer cell-derived MP carry and transfer MDR molecules to non-resistant cancer cells, which can then establish multifactorial resistance.

Mentions: In summary, resistant cancer cell-derived MP carry and transfer MDR and anti-apoptotic molecules to sensitive cancer cells, which can then establish drug resistance. In addition, MP induce the activation of oncogenic pathways and transfer miR, which contribute to the malignant and multifactorial resistant phenotypes of these cells (Fig.7).


Microparticles induce multifactorial resistance through oncogenic pathways independently of cancer cell type.

de Souza PS, Cruz AL, Viola JP, Maia RC - Cancer Sci. (2014)

Schematic diagram of multifactorial phenotype acquisition. Multidrug resistant (MDR) cancer cell-derived MP carry and transfer MDR molecules to non-resistant cancer cells, which can then establish multifactorial resistance.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317771&req=5

fig07: Schematic diagram of multifactorial phenotype acquisition. Multidrug resistant (MDR) cancer cell-derived MP carry and transfer MDR molecules to non-resistant cancer cells, which can then establish multifactorial resistance.
Mentions: In summary, resistant cancer cell-derived MP carry and transfer MDR and anti-apoptotic molecules to sensitive cancer cells, which can then establish drug resistance. In addition, MP induce the activation of oncogenic pathways and transfer miR, which contribute to the malignant and multifactorial resistant phenotypes of these cells (Fig.7).

Bottom Line: By co-culturing MP derived from MDR-positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA.In addition, MP promoted microRNA transfer and NFκB and Yb-1 activation.Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.

View Article: PubMed Central - PubMed

Affiliation: Program of Hemato-Oncology Molecular, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.

Show MeSH
Related in: MedlinePlus