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Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.

Wang CT, Wang DB, Liu KR, Li Y, Sun CX, Guo CS, Ren F - Cancer Sci. (2014)

Bottom Line: The same tendency was found in the corresponding eutopic endometria.The induced malignant endometriosis showed similarities with human disease in the pathological process and histomorphological and molecular biological features.The method is feasible.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.

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Related in: MedlinePlus

Immunostaining of phosphatase and tensin homolog (PTEN) in benign (a), atypical (b), and malignant endometriosis (EMs) (c) (400×) in a rat model. Immunostaining of phosphorylated protein kinase B (p-AKT) in benign (e), atypical (f) and malignant EMs (g) (400×). Immunostaining of phosphorylated mammalian target of rapamycin (p-mTOR) in benign (i), atypical (j), and malignant EMs (k) (400×). H-score values of PTEN (d), p-AKT (h), and p-mTOR (l) immunostaining in EMs, atypical EMs, and malignant EMs.
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fig03: Immunostaining of phosphatase and tensin homolog (PTEN) in benign (a), atypical (b), and malignant endometriosis (EMs) (c) (400×) in a rat model. Immunostaining of phosphorylated protein kinase B (p-AKT) in benign (e), atypical (f) and malignant EMs (g) (400×). Immunostaining of phosphorylated mammalian target of rapamycin (p-mTOR) in benign (i), atypical (j), and malignant EMs (k) (400×). H-score values of PTEN (d), p-AKT (h), and p-mTOR (l) immunostaining in EMs, atypical EMs, and malignant EMs.

Mentions: The samples with simple hyperplasia and atrophy were excluded. The staining of PTEN was weakened, and stainings of p-AKT and p-mTOR were intensified progressively in the order of EMs, atypical EMs, and malignant EMs (P < 0.05). The samples with the same pathological changes showed no significant difference in the abovementioned stainings, regardless of the treatment group or whether the samples were eutopic or ectopic (P > 0.05). The differences in the H-score for PTEN, p-AKT, and p-mTOR among groups are shown in Figure3 and Table3.


Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.

Wang CT, Wang DB, Liu KR, Li Y, Sun CX, Guo CS, Ren F - Cancer Sci. (2014)

Immunostaining of phosphatase and tensin homolog (PTEN) in benign (a), atypical (b), and malignant endometriosis (EMs) (c) (400×) in a rat model. Immunostaining of phosphorylated protein kinase B (p-AKT) in benign (e), atypical (f) and malignant EMs (g) (400×). Immunostaining of phosphorylated mammalian target of rapamycin (p-mTOR) in benign (i), atypical (j), and malignant EMs (k) (400×). H-score values of PTEN (d), p-AKT (h), and p-mTOR (l) immunostaining in EMs, atypical EMs, and malignant EMs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317770&req=5

fig03: Immunostaining of phosphatase and tensin homolog (PTEN) in benign (a), atypical (b), and malignant endometriosis (EMs) (c) (400×) in a rat model. Immunostaining of phosphorylated protein kinase B (p-AKT) in benign (e), atypical (f) and malignant EMs (g) (400×). Immunostaining of phosphorylated mammalian target of rapamycin (p-mTOR) in benign (i), atypical (j), and malignant EMs (k) (400×). H-score values of PTEN (d), p-AKT (h), and p-mTOR (l) immunostaining in EMs, atypical EMs, and malignant EMs.
Mentions: The samples with simple hyperplasia and atrophy were excluded. The staining of PTEN was weakened, and stainings of p-AKT and p-mTOR were intensified progressively in the order of EMs, atypical EMs, and malignant EMs (P < 0.05). The samples with the same pathological changes showed no significant difference in the abovementioned stainings, regardless of the treatment group or whether the samples were eutopic or ectopic (P > 0.05). The differences in the H-score for PTEN, p-AKT, and p-mTOR among groups are shown in Figure3 and Table3.

Bottom Line: The same tendency was found in the corresponding eutopic endometria.The induced malignant endometriosis showed similarities with human disease in the pathological process and histomorphological and molecular biological features.The method is feasible.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.

Show MeSH
Related in: MedlinePlus