Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.
Bottom Line: The same tendency was found in the corresponding eutopic endometria.The induced malignant endometriosis showed similarities with human disease in the pathological process and histomorphological and molecular biological features.The method is feasible.
Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.Show MeSH
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Mentions: The atrophy and simple hyperplastic EMs were excluded from the proliferation and apoptosis analysis. In the Es group, the immunostaining of PCNA protein increased (P < 0.01), and the level of TUNEL positivity decreased (P < 0.01) progressively in the order of EMs, atypical EMs, and malignant EMs. The immunostaining of PCNA in EMs of the Es group was stronger than that of the control group (P < 0.05), and the staining intensity of apoptosis in the Es group was lower than that of the control group (P < 0.05) (Fig.2).
Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.