Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes.
Bottom Line: The same tendency was found in the corresponding eutopic endometria.The induced malignant endometriosis showed similarities with human disease in the pathological process and histomorphological and molecular biological features.The method is feasible.
Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.Show MeSH
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Mentions: Two cases of EMs in the Es group (8 months after surgery) were extraordinarily enlarged (Fig.1a). Grossly, the two were cystic, consisted of thickened capsule wall with papillary hyperplasia and sanguinopurulent fluid (H&E stain revealed malignancy). Endometriosis of the control group (Fig.1b) had the appearance of unilocular cystic structures filled with clear fluid. The uteri of the Es group showed severe edema, with no papillary hyperplasia, whereas uteri of the control group showed no obvious abnormality.
Affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.