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Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats.

Young AM, Stubbendorff C, Valencia M, Gerdjikov TV - Neuroscience (2014)

Bottom Line: We found that this regimen reduced theta oscillations in the medial prefrontal cortex.It further produced abnormal cortical synchronization in putative cortical pyramidal cells.These alterations in prefrontal cortex functioning may contribute to cognitive deficits seen in subchronic NMDA antagonist pre-treated animals in prefrontal-dependent tasks.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, College of Medicine, Biological Sciences and Psychology, University of Leicester, United Kingdom.

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Related in: MedlinePlus

Power spectral density (PSD) of mPFC oscillatory activity shows a significant decrease in theta power in PCP-treated animals. (A) Power spectral density of mPFC oscillatory activity in vehicle- and PCP-treated animals. Data are depicted as mean ± CI, gray traces for vehicle, red for PCP-treated animals. (B) Box-plot representation for the energy at each of the frequency bands of interest for the vehicle (black boxes) and PCP-treated conditions (red boxes). Statistical tests (Mann–Whitney U test) reveal a significant decrease (p = 0.04) in the energy of the theta band (4–7.5 Hz). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
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f0005: Power spectral density (PSD) of mPFC oscillatory activity shows a significant decrease in theta power in PCP-treated animals. (A) Power spectral density of mPFC oscillatory activity in vehicle- and PCP-treated animals. Data are depicted as mean ± CI, gray traces for vehicle, red for PCP-treated animals. (B) Box-plot representation for the energy at each of the frequency bands of interest for the vehicle (black boxes) and PCP-treated conditions (red boxes). Statistical tests (Mann–Whitney U test) reveal a significant decrease (p = 0.04) in the energy of the theta band (4–7.5 Hz). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Mentions: Spectral analysis of LFP activity from mPFC of vehicle- or PCP-treated rats showed that the predominant activity in both groups was gathered in the lower frequency ranges (Fig. 1A). Qualitatively, PCP-treated rats showed a decrease in the energy of the oscillatory activity at the lower frequency bands (Fig. 1B). Significant statistical differences emerged for the theta range (Mann–Whitney U test, p = 0.0 4). For higher frequencies, the spectra of both groups decayed monotonically and no prominent activity was detected.


Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats.

Young AM, Stubbendorff C, Valencia M, Gerdjikov TV - Neuroscience (2014)

Power spectral density (PSD) of mPFC oscillatory activity shows a significant decrease in theta power in PCP-treated animals. (A) Power spectral density of mPFC oscillatory activity in vehicle- and PCP-treated animals. Data are depicted as mean ± CI, gray traces for vehicle, red for PCP-treated animals. (B) Box-plot representation for the energy at each of the frequency bands of interest for the vehicle (black boxes) and PCP-treated conditions (red boxes). Statistical tests (Mann–Whitney U test) reveal a significant decrease (p = 0.04) in the energy of the theta band (4–7.5 Hz). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317768&req=5

f0005: Power spectral density (PSD) of mPFC oscillatory activity shows a significant decrease in theta power in PCP-treated animals. (A) Power spectral density of mPFC oscillatory activity in vehicle- and PCP-treated animals. Data are depicted as mean ± CI, gray traces for vehicle, red for PCP-treated animals. (B) Box-plot representation for the energy at each of the frequency bands of interest for the vehicle (black boxes) and PCP-treated conditions (red boxes). Statistical tests (Mann–Whitney U test) reveal a significant decrease (p = 0.04) in the energy of the theta band (4–7.5 Hz). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Mentions: Spectral analysis of LFP activity from mPFC of vehicle- or PCP-treated rats showed that the predominant activity in both groups was gathered in the lower frequency ranges (Fig. 1A). Qualitatively, PCP-treated rats showed a decrease in the energy of the oscillatory activity at the lower frequency bands (Fig. 1B). Significant statistical differences emerged for the theta range (Mann–Whitney U test, p = 0.0 4). For higher frequencies, the spectra of both groups decayed monotonically and no prominent activity was detected.

Bottom Line: We found that this regimen reduced theta oscillations in the medial prefrontal cortex.It further produced abnormal cortical synchronization in putative cortical pyramidal cells.These alterations in prefrontal cortex functioning may contribute to cognitive deficits seen in subchronic NMDA antagonist pre-treated animals in prefrontal-dependent tasks.

View Article: PubMed Central - PubMed

Affiliation: School of Psychology, College of Medicine, Biological Sciences and Psychology, University of Leicester, United Kingdom.

Show MeSH
Related in: MedlinePlus