Disruption of medial prefrontal synchrony in the subchronic phencyclidine model of schizophrenia in rats.
Bottom Line: We found that this regimen reduced theta oscillations in the medial prefrontal cortex.It further produced abnormal cortical synchronization in putative cortical pyramidal cells.These alterations in prefrontal cortex functioning may contribute to cognitive deficits seen in subchronic NMDA antagonist pre-treated animals in prefrontal-dependent tasks.
Affiliation: School of Psychology, College of Medicine, Biological Sciences and Psychology, University of Leicester, United Kingdom.Show MeSH
Related in: MedlinePlus
Mentions: Spectral analysis of LFP activity from mPFC of vehicle- or PCP-treated rats showed that the predominant activity in both groups was gathered in the lower frequency ranges (Fig. 1A). Qualitatively, PCP-treated rats showed a decrease in the energy of the oscillatory activity at the lower frequency bands (Fig. 1B). Significant statistical differences emerged for the theta range (Mann–Whitney U test, p = 0.0 4). For higher frequencies, the spectra of both groups decayed monotonically and no prominent activity was detected.
Affiliation: School of Psychology, College of Medicine, Biological Sciences and Psychology, University of Leicester, United Kingdom.