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Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Kosmidis E, Vogl T, Linsmeier B, Tsakiridis K, Lampaki S, Lazaridis G, Mpakas A, Browning R, Papaiwannou A, Drevelegas A, Baka S, Karavasilis V, Mpoukovinas I, Turner JF, Zarogoulidis K, Brachmann J - J Cancer (2015)

Bottom Line: Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect.Future modification of lipiodol might provide a more efficient method of therapy enhancement.Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

View Article: PubMed Central - PubMed

Affiliation: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.

ABSTRACT
Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

No MeSH data available.


Related in: MedlinePlus

Cisplatin and Microwave; T1 sequence: Heterogeneous appearance in the central part of the tumor, low intensity indicates necrosis. T2 sequence: High signal intensity indicates necrosis. White arrow indicates area where the microwave spike was inserted.
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Figure 12: Cisplatin and Microwave; T1 sequence: Heterogeneous appearance in the central part of the tumor, low intensity indicates necrosis. T2 sequence: High signal intensity indicates necrosis. White arrow indicates area where the microwave spike was inserted.

Mentions: Tumor necrosis and apoptosis were the major purposes of our study. Survival was also recorded. Our records and MRI findings indicate that a major toxicity was observed in the group where cisplatin, lipiodol and microwave were applied. None of the animals survived more than a week. Moreover; hemorrhage apart from necrosis was observed inside the tumors. Survival was the following for the groups: microwave (25days) ≥ cisplatin (22 days) > control (20 days) > lipiodol (16 days)> microwave plus lipiodol (16 days) > cisplatin plus lipiodol (12) > cisplatin plus microwave (12 days) > lipiodol plus cisplatin plus microwave (5 days). (Figure 5-12.)


Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Kosmidis E, Vogl T, Linsmeier B, Tsakiridis K, Lampaki S, Lazaridis G, Mpakas A, Browning R, Papaiwannou A, Drevelegas A, Baka S, Karavasilis V, Mpoukovinas I, Turner JF, Zarogoulidis K, Brachmann J - J Cancer (2015)

Cisplatin and Microwave; T1 sequence: Heterogeneous appearance in the central part of the tumor, low intensity indicates necrosis. T2 sequence: High signal intensity indicates necrosis. White arrow indicates area where the microwave spike was inserted.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4317756&req=5

Figure 12: Cisplatin and Microwave; T1 sequence: Heterogeneous appearance in the central part of the tumor, low intensity indicates necrosis. T2 sequence: High signal intensity indicates necrosis. White arrow indicates area where the microwave spike was inserted.
Mentions: Tumor necrosis and apoptosis were the major purposes of our study. Survival was also recorded. Our records and MRI findings indicate that a major toxicity was observed in the group where cisplatin, lipiodol and microwave were applied. None of the animals survived more than a week. Moreover; hemorrhage apart from necrosis was observed inside the tumors. Survival was the following for the groups: microwave (25days) ≥ cisplatin (22 days) > control (20 days) > lipiodol (16 days)> microwave plus lipiodol (16 days) > cisplatin plus lipiodol (12) > cisplatin plus microwave (12 days) > lipiodol plus cisplatin plus microwave (5 days). (Figure 5-12.)

Bottom Line: Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect.Future modification of lipiodol might provide a more efficient method of therapy enhancement.Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

View Article: PubMed Central - PubMed

Affiliation: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.

ABSTRACT
Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

No MeSH data available.


Related in: MedlinePlus