Limits...
Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Kosmidis E, Vogl T, Linsmeier B, Tsakiridis K, Lampaki S, Lazaridis G, Mpakas A, Browning R, Papaiwannou A, Drevelegas A, Baka S, Karavasilis V, Mpoukovinas I, Turner JF, Zarogoulidis K, Brachmann J - J Cancer (2015)

Bottom Line: Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect.Future modification of lipiodol might provide a more efficient method of therapy enhancement.Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

View Article: PubMed Central - PubMed

Affiliation: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.

ABSTRACT
Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

No MeSH data available.


Related in: MedlinePlus

Letters A,B and C indicate the site of drug administration (Cisplatin and lipidilol) while in the center of the tumor the microwave ablation spike was inserted. We used a 17cm spike as this was available to us and only 0.5-1 cm was inserted in the center of the tumor.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC4317756&req=5

Figure 4: Letters A,B and C indicate the site of drug administration (Cisplatin and lipidilol) while in the center of the tumor the microwave ablation spike was inserted. We used a 17cm spike as this was available to us and only 0.5-1 cm was inserted in the center of the tumor.

Mentions: Cisplatin, and lipiodol were administered with an insulin syringe not in one spot, but in three different spots as indicated in Figure 4. The reason for this methodology was the concept of enhancing the therapy or lipiodol effect by distributing the drug in different parts of the tumor. On the other hand the microwave ablation spike was inserted in the center of the tumor, since the tumor was not larger than one cm in diameter. As it is indicated by the manufacturer (http://surgical.covidien.com/products/ablation-systems/microwave-ablation/evident-mwa-antennas) there is no need to insert an additional spike. The application was performed with 45 watts over 10 minutes. We used a 17cm spike as this was available to us. Each spike was only 0.5-1 cm inserted in the center of the tumor. Cisplatin dosage was 1ml divided in three sites, and the same was applied for lipiodol.


Enhancement of Intratumoral Chemotherapy with Cisplatin with or without Microwave Ablation and Lipiodol. Future Concept for Local Treatment in Lung Cancer.

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Kosmidis E, Vogl T, Linsmeier B, Tsakiridis K, Lampaki S, Lazaridis G, Mpakas A, Browning R, Papaiwannou A, Drevelegas A, Baka S, Karavasilis V, Mpoukovinas I, Turner JF, Zarogoulidis K, Brachmann J - J Cancer (2015)

Letters A,B and C indicate the site of drug administration (Cisplatin and lipidilol) while in the center of the tumor the microwave ablation spike was inserted. We used a 17cm spike as this was available to us and only 0.5-1 cm was inserted in the center of the tumor.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4317756&req=5

Figure 4: Letters A,B and C indicate the site of drug administration (Cisplatin and lipidilol) while in the center of the tumor the microwave ablation spike was inserted. We used a 17cm spike as this was available to us and only 0.5-1 cm was inserted in the center of the tumor.
Mentions: Cisplatin, and lipiodol were administered with an insulin syringe not in one spot, but in three different spots as indicated in Figure 4. The reason for this methodology was the concept of enhancing the therapy or lipiodol effect by distributing the drug in different parts of the tumor. On the other hand the microwave ablation spike was inserted in the center of the tumor, since the tumor was not larger than one cm in diameter. As it is indicated by the manufacturer (http://surgical.covidien.com/products/ablation-systems/microwave-ablation/evident-mwa-antennas) there is no need to insert an additional spike. The application was performed with 45 watts over 10 minutes. We used a 17cm spike as this was available to us. Each spike was only 0.5-1 cm inserted in the center of the tumor. Cisplatin dosage was 1ml divided in three sites, and the same was applied for lipiodol.

Bottom Line: Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect.Future modification of lipiodol might provide a more efficient method of therapy enhancement.Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

View Article: PubMed Central - PubMed

Affiliation: 1. II Medical Clinic, "Coburg" Hospital, University of Wuerzburg, Coburg, Germany.

ABSTRACT
Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (10(6)) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm(3) the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

No MeSH data available.


Related in: MedlinePlus