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Renal failure caused by malakoplakia lesions of the urinary bladder.

Stamatiou K, Chelioti E, Tsavari A, Koulia K, Papalexandrou A, Efthymiou E, Tsilivigkou M, Vasilakaki T - Nephrourol Mon (2014)

Bottom Line: Μalakoplakia is a rare inflammatory condition of the urogenital tract.The most frequently affected organ is urinary bladder.In this study, we presented a case of urinary bladder malakoplakia associated with advanced obstructive uropathy and renal failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, "Tzaneion" General Hospital of Piraeus, Athens, Greece.

ABSTRACT
Μalakoplakia is a rare inflammatory condition of the urogenital tract. The most frequently affected organ is urinary bladder. This condition has features of a granulomatous inflammation, the pathogenesis of which is not well understood. In this study, we presented a case of urinary bladder malakoplakia associated with advanced obstructive uropathy and renal failure.

No MeSH data available.


Related in: MedlinePlus

Pathognomonic Histological Inflammatory Infiltrates (ΗΕx100)
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fig12091: Pathognomonic Histological Inflammatory Infiltrates (ΗΕx100)

Mentions: He subsequently underwent transurethral resection of the bladder lesions. Cystectomy was not performed, because the patient was too frail to undergo such a long surgery. On the histologic examination of the bladder specimens, aggregates of large macrophages with fine eosinophilic granular cytoplasm (von Hansemann cells) admixed with basophilic inclusions (Michaelis-Gutmann bodies) and infiltrated by dense collections of lymphocytes, as well as plasma cells, were seen in lamina propria of urinary bladder (Figures 2, 3 and 4). Macrophages were immunohistochemically negative for cytokeratin and positive for CD68. Immunohistochemical examination of proliferative activity, measured by Ki-67 in malakoplakia, was negative. Despite the absence of bacteria in the urinalysis, the patient received quinolones for three months, according to the current evidence. However, the patient remained with UTIs, chronic hydronephrosis, renal failure, and permanent bladder catheter. Finally, he died eight months later, after a further worsening of renal failure and complications of the cardiovascular system.


Renal failure caused by malakoplakia lesions of the urinary bladder.

Stamatiou K, Chelioti E, Tsavari A, Koulia K, Papalexandrou A, Efthymiou E, Tsilivigkou M, Vasilakaki T - Nephrourol Mon (2014)

Pathognomonic Histological Inflammatory Infiltrates (ΗΕx100)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317724&req=5

fig12091: Pathognomonic Histological Inflammatory Infiltrates (ΗΕx100)
Mentions: He subsequently underwent transurethral resection of the bladder lesions. Cystectomy was not performed, because the patient was too frail to undergo such a long surgery. On the histologic examination of the bladder specimens, aggregates of large macrophages with fine eosinophilic granular cytoplasm (von Hansemann cells) admixed with basophilic inclusions (Michaelis-Gutmann bodies) and infiltrated by dense collections of lymphocytes, as well as plasma cells, were seen in lamina propria of urinary bladder (Figures 2, 3 and 4). Macrophages were immunohistochemically negative for cytokeratin and positive for CD68. Immunohistochemical examination of proliferative activity, measured by Ki-67 in malakoplakia, was negative. Despite the absence of bacteria in the urinalysis, the patient received quinolones for three months, according to the current evidence. However, the patient remained with UTIs, chronic hydronephrosis, renal failure, and permanent bladder catheter. Finally, he died eight months later, after a further worsening of renal failure and complications of the cardiovascular system.

Bottom Line: Μalakoplakia is a rare inflammatory condition of the urogenital tract.The most frequently affected organ is urinary bladder.In this study, we presented a case of urinary bladder malakoplakia associated with advanced obstructive uropathy and renal failure.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, "Tzaneion" General Hospital of Piraeus, Athens, Greece.

ABSTRACT
Μalakoplakia is a rare inflammatory condition of the urogenital tract. The most frequently affected organ is urinary bladder. This condition has features of a granulomatous inflammation, the pathogenesis of which is not well understood. In this study, we presented a case of urinary bladder malakoplakia associated with advanced obstructive uropathy and renal failure.

No MeSH data available.


Related in: MedlinePlus