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Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups.

Meng HT, Zhang YD, Shen CM, Yuan GL, Yang CH, Jin R, Yan JW, Wang HD, Liu WJ, Jing H, Zhu BF - Sci Rep (2015)

Bottom Line: The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus.Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups.Further studies should be conducted for better understanding of the Xibe genetic background.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an. 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus. The cumulative power of exclusion and total probability of discrimination power in the studied group were 0.9867 and 0.9999999999902 for the 30 loci, respectively. Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups. The results indicated that these 30 loci should only be used as a complement for autosomal STRs in paternity cases but could provide an acceptable level of discrimination in forensic identification cases in the studied Xibe group. Further studies should be conducted for better understanding of the Xibe genetic background.

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PCA based on 30 InDel loci of Xibe and 10 reference groups.
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f2: PCA based on 30 InDel loci of Xibe and 10 reference groups.

Mentions: PCA was performed among the studied Xibe group and other 10 reference groups on the 30 InDel loci. The result was shown in Fig. 2. The first two principal components defined 85.17% of the total variance, with the first and second component accounted for 77.62% and 7.55%, respectively. According to the figure, the 4 European groups and 5 Asian groups distributed in the right and left part, respectively, with the 2 Eurasian groups (Kazak and Uigur groups) located between them, that is, in the middle of the plot. The studied Xibe group clustered in the upper left quadrant, close to Beijing Han, Guangdong Han and South Korean populations, indicating the close genetic relationships between the studied Xibe group and these groups.


Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups.

Meng HT, Zhang YD, Shen CM, Yuan GL, Yang CH, Jin R, Yan JW, Wang HD, Liu WJ, Jing H, Zhu BF - Sci Rep (2015)

PCA based on 30 InDel loci of Xibe and 10 reference groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317707&req=5

f2: PCA based on 30 InDel loci of Xibe and 10 reference groups.
Mentions: PCA was performed among the studied Xibe group and other 10 reference groups on the 30 InDel loci. The result was shown in Fig. 2. The first two principal components defined 85.17% of the total variance, with the first and second component accounted for 77.62% and 7.55%, respectively. According to the figure, the 4 European groups and 5 Asian groups distributed in the right and left part, respectively, with the 2 Eurasian groups (Kazak and Uigur groups) located between them, that is, in the middle of the plot. The studied Xibe group clustered in the upper left quadrant, close to Beijing Han, Guangdong Han and South Korean populations, indicating the close genetic relationships between the studied Xibe group and these groups.

Bottom Line: The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus.Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups.Further studies should be conducted for better understanding of the Xibe genetic background.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an. 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus. The cumulative power of exclusion and total probability of discrimination power in the studied group were 0.9867 and 0.9999999999902 for the 30 loci, respectively. Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups. The results indicated that these 30 loci should only be used as a complement for autosomal STRs in paternity cases but could provide an acceptable level of discrimination in forensic identification cases in the studied Xibe group. Further studies should be conducted for better understanding of the Xibe genetic background.

Show MeSH