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Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups.

Meng HT, Zhang YD, Shen CM, Yuan GL, Yang CH, Jin R, Yan JW, Wang HD, Liu WJ, Jing H, Zhu BF - Sci Rep (2015)

Bottom Line: The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus.Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups.Further studies should be conducted for better understanding of the Xibe genetic background.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an. 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus. The cumulative power of exclusion and total probability of discrimination power in the studied group were 0.9867 and 0.9999999999902 for the 30 loci, respectively. Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups. The results indicated that these 30 loci should only be used as a complement for autosomal STRs in paternity cases but could provide an acceptable level of discrimination in forensic identification cases in the studied Xibe group. Further studies should be conducted for better understanding of the Xibe genetic background.

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Clustering analysis by structure for the full-loci dataset assuming K = 2–7.Population names were labeled beneath.
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f1: Clustering analysis by structure for the full-loci dataset assuming K = 2–7.Population names were labeled beneath.

Mentions: We analyzed the population structures of the studied Xibe group and 10 referenced groups (South Korean31, (Madrid) Central Spanish, Basque (Northern Spanish)32, Hungarian33, Dane34, Beijing Han (Northern Han Chinese), Tibetan, Uigur, Kazak22 and Guangdong Han (Southern Han Chinese)35) by the structure program. The result was shown in Fig. 1. At K = 2, the clusters were anchored by Europe and Asia, and the 4 European groups and 5 Asian groups were constituted almost entirely by green and red component, respectively. At the same time, Kazak and Uigur group showed a mixed constitution of both green and red component. At K > 2, the 4 European groups and the 2 Eurasian groups (Kazak and Uigur groups) all had a mean component representing the European descent, while the 5 Asian groups had partial membership in K-1 clusters with similar membership proportions. According to the structure manual30, this indicated that the 5 groups showed similar membership proportions at the 30 loci. Moreover, as mentioned by Rosenberg et al., groups which had similar membership proportions in different clusters might reflect continuous gradations in allele frequencies across regions or admixture of neighboring groups36.


Genetic polymorphism analyses of 30 InDels in Chinese Xibe ethnic group and its population genetic differentiations with other groups.

Meng HT, Zhang YD, Shen CM, Yuan GL, Yang CH, Jin R, Yan JW, Wang HD, Liu WJ, Jing H, Zhu BF - Sci Rep (2015)

Clustering analysis by structure for the full-loci dataset assuming K = 2–7.Population names were labeled beneath.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317707&req=5

f1: Clustering analysis by structure for the full-loci dataset assuming K = 2–7.Population names were labeled beneath.
Mentions: We analyzed the population structures of the studied Xibe group and 10 referenced groups (South Korean31, (Madrid) Central Spanish, Basque (Northern Spanish)32, Hungarian33, Dane34, Beijing Han (Northern Han Chinese), Tibetan, Uigur, Kazak22 and Guangdong Han (Southern Han Chinese)35) by the structure program. The result was shown in Fig. 1. At K = 2, the clusters were anchored by Europe and Asia, and the 4 European groups and 5 Asian groups were constituted almost entirely by green and red component, respectively. At the same time, Kazak and Uigur group showed a mixed constitution of both green and red component. At K > 2, the 4 European groups and the 2 Eurasian groups (Kazak and Uigur groups) all had a mean component representing the European descent, while the 5 Asian groups had partial membership in K-1 clusters with similar membership proportions. According to the structure manual30, this indicated that the 5 groups showed similar membership proportions at the 30 loci. Moreover, as mentioned by Rosenberg et al., groups which had similar membership proportions in different clusters might reflect continuous gradations in allele frequencies across regions or admixture of neighboring groups36.

Bottom Line: The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus.Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups.Further studies should be conducted for better understanding of the Xibe genetic background.

View Article: PubMed Central - PubMed

Affiliation: 1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an. 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.

ABSTRACT
In the present study, we obtained population genetic data and forensic parameters of 30 InDel loci in Chinese Xibe ethnic group from northwestern China and studied the genetic relationships between the studied Xibe group and other reference groups. The observed heterozygosities ranged from 0.1704 at HLD118 locus to 0.5247 at HLD92 locus while the expected heterozygosities ranged from 0.1559 at HLD118 locus to 0.4997 at HLD101 locus. The cumulative power of exclusion and total probability of discrimination power in the studied group were 0.9867 and 0.9999999999902 for the 30 loci, respectively. Analyses of structure, PCA, interpopulation differentiations and phylogenetic tree revealed that the Xibe group had close genetic relationships with South Korean, Beijing Han and Guangdong Han groups. The results indicated that these 30 loci should only be used as a complement for autosomal STRs in paternity cases but could provide an acceptable level of discrimination in forensic identification cases in the studied Xibe group. Further studies should be conducted for better understanding of the Xibe genetic background.

Show MeSH
Related in: MedlinePlus