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Effects of calcium phosphate nanocrystals on osseointegration of titanium implant in irradiated bone.

Li JY, Pow EH, Zheng LW, Ma L, Kwong DL, Cheung LK - Biomed Res Int (2015)

Bottom Line: The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after.Four animals in each group were sacrificed after 4 and 12 weeks, respectively.No significant differences in BV/TV and BIC were found between two groups.

View Article: PubMed Central - PubMed

Affiliation: Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.

ABSTRACT
Radiotherapy may compromise the integration of implant and cause implant loss. Implant surface modifications have the possibility of promoting cell attachment, cell growth, and bone formation which ultimately enhance the osseointegration process. The present study aimed to investigate the effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were randomly assigned into control and nano-CaP groups, receiving implants with dual acid-etched surface or dual acid-etched surface discretely deposited of nanoscale calcium-phosphate crystals, respectively. The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after. Four animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 6, P = 0.021; week 9, P = 0.001) than that in control group. No significant differences in BV/TV and BIC were found between two groups. Titanium implant surface modified with CaP nanocrystals provides a potential alternative to improve bone healing around implant in irradiated bone.

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Related in: MedlinePlus

Micro-CT 3D images. (a) Control implant at week 4; (b) nano-CaP implant at week 4; (c) control implant at week 12; (d) nano-CaP implant at week 12. Green color represents implant surface and grey color represents bone.
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fig1: Micro-CT 3D images. (a) Control implant at week 4; (b) nano-CaP implant at week 4; (c) control implant at week 12; (d) nano-CaP implant at week 12. Green color represents implant surface and grey color represents bone.

Mentions: The representative images of micro-CT three-dimensional (3D) models of bone formation around implants are shown in Figure 1. The BV/TV at week 12 was significantly higher than that at week 4 in both groups (control: P = 0.042; nano-CaP: P = 0.005) (Table 2). No significant difference of BV/TV was found between control and nano-CaP groups at week 4 (P = 0.579) and week 12 (P = 0.724).


Effects of calcium phosphate nanocrystals on osseointegration of titanium implant in irradiated bone.

Li JY, Pow EH, Zheng LW, Ma L, Kwong DL, Cheung LK - Biomed Res Int (2015)

Micro-CT 3D images. (a) Control implant at week 4; (b) nano-CaP implant at week 4; (c) control implant at week 12; (d) nano-CaP implant at week 12. Green color represents implant surface and grey color represents bone.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4317600&req=5

fig1: Micro-CT 3D images. (a) Control implant at week 4; (b) nano-CaP implant at week 4; (c) control implant at week 12; (d) nano-CaP implant at week 12. Green color represents implant surface and grey color represents bone.
Mentions: The representative images of micro-CT three-dimensional (3D) models of bone formation around implants are shown in Figure 1. The BV/TV at week 12 was significantly higher than that at week 4 in both groups (control: P = 0.042; nano-CaP: P = 0.005) (Table 2). No significant difference of BV/TV was found between control and nano-CaP groups at week 4 (P = 0.579) and week 12 (P = 0.724).

Bottom Line: The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after.Four animals in each group were sacrificed after 4 and 12 weeks, respectively.No significant differences in BV/TV and BIC were found between two groups.

View Article: PubMed Central - PubMed

Affiliation: Oral Rehabilitation, Faculty of Dentistry, The University of Hong Kong, Hong Kong.

ABSTRACT
Radiotherapy may compromise the integration of implant and cause implant loss. Implant surface modifications have the possibility of promoting cell attachment, cell growth, and bone formation which ultimately enhance the osseointegration process. The present study aimed to investigate the effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Sixteen rabbits were randomly assigned into control and nano-CaP groups, receiving implants with dual acid-etched surface or dual acid-etched surface discretely deposited of nanoscale calcium-phosphate crystals, respectively. The left leg of all the rabbits received 15 Gy radiation, followed by implants placement one week after. Four animals in each group were sacrificed after 4 and 12 weeks, respectively. Implant stability quotient (ISQ), ratio of bone volume to total volume (BV/TV), bone growth rate, and bone-to-implant contact (BIC) were evaluated. The nano-CaP group showed significantly higher ISQ (week 12, P = 0.031) and bone growth rate (week 6, P = 0.021; week 9, P = 0.001) than that in control group. No significant differences in BV/TV and BIC were found between two groups. Titanium implant surface modified with CaP nanocrystals provides a potential alternative to improve bone healing around implant in irradiated bone.

Show MeSH
Related in: MedlinePlus