Impaired threat prioritisation after selective bilateral amygdala lesions.
Bottom Line: Here we use a face-in-the-crowd (FITC) task which in healthy control individuals reveals prioritised threat processing, evident in faster serial search for angry compared to happy target faces.In lesion patients we show a reversal of a threat detection advantage indicating a profound impairment in prioritising threat information.This is the first direct demonstration that human amygdala lesions impair prioritisation of threatening faces, providing evidence that this structure has a causal role in responding to imminent danger.
Affiliation: Wellcome Trust Centre for Neuroimaging, University College London, UK; Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, Switzerland. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: In our control sample, set size, target emotion, and target presence influenced RT as shown previously (see Fig. 2A and Table 1), with a linear impact of set size. This result was confirmed by fitting a linear regression model to predict RT from set size, separately for each combination of target presence and target emotion. An ANOVA on search slope estimates (Table 2) underlines that search slope is influenced by target face – angry target faces have a shallower search slope – and by target presence. There were no effects in an ANOVA on intercepts of the regression model, as expected.
Affiliation: Wellcome Trust Centre for Neuroimaging, University College London, UK; Department of Psychiatry, Psychotherapy, and Psychosomatics, University of Zurich, Switzerland. Electronic address: email@example.com.