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Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome.

Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME - Exp Ther Med (2014)

Bottom Line: Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01).The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05).These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Bilim University, Istanbul 34394, Turkey.

ABSTRACT

To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol-induced oxidative stress on the cerebral cortex of newborn rat pups and assess the protective and beneficial effects of BA supplementation on rats with FAS. Pregnant rats were divided into three groups, namely the control, alcohol and alcohol + boric acid groups. As markers of alcohol-induced oxidative stress in the cerebral cortex of the newborn pups, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were measured. Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01). The CAT activity of the alcohol + boric acid group was significantly higher than that in the alcohol group (P<0.05). The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05). These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.

No MeSH data available.


Related in: MedlinePlus

Effect of boric acid on malondialdehyde (MDA) levels in rats exposed to alcohol. *P<0.05; **P<0.01. Data shown are mean ± standard deviation.
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f2-etm-09-03-1023: Effect of boric acid on malondialdehyde (MDA) levels in rats exposed to alcohol. *P<0.05; **P<0.01. Data shown are mean ± standard deviation.

Mentions: MDA levels in the alcohol group (7.53±1.41 nmol/mg protein) were significantly increased (P<0.05) compared with the control level (6.11±1.11 nmol/mg protein). The MDA level in the alcohol + boric acid group (5.74±1.22) exhibited a significant reduction (P<0.01) compared with that in the alcohol group (Fig. 2).


Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome.

Sogut I, Oglakci A, Kartkaya K, Ol KK, Sogut MS, Kanbak G, Inal ME - Exp Ther Med (2014)

Effect of boric acid on malondialdehyde (MDA) levels in rats exposed to alcohol. *P<0.05; **P<0.01. Data shown are mean ± standard deviation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4316929&req=5

f2-etm-09-03-1023: Effect of boric acid on malondialdehyde (MDA) levels in rats exposed to alcohol. *P<0.05; **P<0.01. Data shown are mean ± standard deviation.
Mentions: MDA levels in the alcohol group (7.53±1.41 nmol/mg protein) were significantly increased (P<0.05) compared with the control level (6.11±1.11 nmol/mg protein). The MDA level in the alcohol + boric acid group (5.74±1.22) exhibited a significant reduction (P<0.01) compared with that in the alcohol group (Fig. 2).

Bottom Line: Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01).The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05).These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Bilim University, Istanbul 34394, Turkey.

ABSTRACT

To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol-induced oxidative stress on the cerebral cortex of newborn rat pups and assess the protective and beneficial effects of BA supplementation on rats with FAS. Pregnant rats were divided into three groups, namely the control, alcohol and alcohol + boric acid groups. As markers of alcohol-induced oxidative stress in the cerebral cortex of the newborn pups, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were measured. Although the MDA levels in the alcohol group were significantly increased compared with those in the control group (P<0.05), the MDA level in the alcohol + boric acid group was shown to be significantly decreased compared with that in the alcohol group (P<0.01). The CAT activity of the alcohol + boric acid group was significantly higher than that in the alcohol group (P<0.05). The GPx activity in the alcohol group was decreased compared with that in the control group (P<0.05). These results demonstrate that alcohol is capable of triggering damage to membranes of the cerebral cortex of rat pups and BA could be influential in antioxidant mechanisms against oxidative stress resulting from prenatal alcohol exposure.

No MeSH data available.


Related in: MedlinePlus