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A confirmed severe case of human infection with avian-origin influenza H7N9: A case report.

Cao HF, Liang ZH, Feng Y, Zhang ZN, Xu J, He H - Exp Ther Med (2014)

Bottom Line: No therapeutic effect was observed with anti-infection treatment.Oxygen saturation decreased and gastrointestinal bleeding occurred, with the body temperature fluctuating between 39 and 40°C.Subsequently, clinical death was declared with the patient exhibiting asystole and no spontaneous breathing.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Jingan District Centre Hospital of Shanghai, Jingan Branch of Huashan Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.

ABSTRACT

A male patient, aged 77 years, was admitted to hospital with the chief complaint of persistent hyperpyrexia that had presented for four days. The patient also suffered from hypoxemia, and a large white shadow in the left lung was observed on a chest radiograph, indicating inflammation. No therapeutic effect was observed with anti-infection treatment. The patient admitted a history of direct contact with live chickens two weeks prior to hospital admission. The day after admission to the Jingnan District Centre Hospital of Shanghai (Shanghai, China), the patient was diagnosed with severe H7N9 avian influenza infection by nasopharyngeal swab and blood sampling detection. Although the patient received anti-infective drugs, intubated assisted ventilation and circulation support, the condition of the patient continued to rapidly deteriorate. Oxygen saturation decreased and gastrointestinal bleeding occurred, with the body temperature fluctuating between 39 and 40°C. By day 6 after admission, the patient presented with circulatory failure, with liver and renal failure. On day 7, the blood pressure of the patient was unable to be measured, and the patient was diagnosed with multiple organ dysfunction. Subsequently, clinical death was declared with the patient exhibiting asystole and no spontaneous breathing.

No MeSH data available.


Related in: MedlinePlus

On April 3rd 2013, the chest radiograph showed the left lower lung with a patchy, fuzzy shadow.
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f1-etm-09-03-0693: On April 3rd 2013, the chest radiograph showed the left lower lung with a patchy, fuzzy shadow.

Mentions: A male patient, aged 77 years, was admitted to the Putuo District People’s Hospital of Shanghai City (Shanghai, China) after presenting with a fever for four days. On April 3rd 2013, the patient experienced chills and fever, without evident cause or regularity, with a maximum temperature of 39.4°C. The patient did not suffer from a cough, expectoration, sore throat, runny nose, chest tightness, chest pain, pant or whole muscle and joint ache. A chest radiograph, obtained in the initial hospital, revealed a fuzzy shadow in the left lower lung (Fig. 1). After intravenous (i.v) treatment with ceftriaxone (2 g/day) and levofloxacin (0.5 g/day) for three days, the fever improved. The patient was admitted to the Jingnan District Centre Hospital of Shanghai (Shanghai, China) with a body temperature of 37.8°C. Emergency blood tests revealed a leukocyte count of 5×109/l (neutrophils, 83.6%) and a C-reactive protein level of 192 mg/l. A chest computed tomography scan (Somatom Definition AS+ 128 Multi-Slice CT Scanner; Siemens, Munich, Germany) revealed a ‘frosted glass’ appearance in both lungs, and a high density shadow was observed in the left lower lobe (Fig. 2). In addition, a bronchiologram revealed inflammation and left lung consolidation. Since the patient was suspected of having pneumonia, the patient was admitted to the Central Hospital of Jingan District for further diagnosis and treatment. This study was conducted in accordance with the Declaration of Helsinki, and with approval from the Ethics Committee of the Central Hospital of Shanghai Jingan District. Written informed consent was obtained from the relatives of the patient.


A confirmed severe case of human infection with avian-origin influenza H7N9: A case report.

Cao HF, Liang ZH, Feng Y, Zhang ZN, Xu J, He H - Exp Ther Med (2014)

On April 3rd 2013, the chest radiograph showed the left lower lung with a patchy, fuzzy shadow.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4316893&req=5

f1-etm-09-03-0693: On April 3rd 2013, the chest radiograph showed the left lower lung with a patchy, fuzzy shadow.
Mentions: A male patient, aged 77 years, was admitted to the Putuo District People’s Hospital of Shanghai City (Shanghai, China) after presenting with a fever for four days. On April 3rd 2013, the patient experienced chills and fever, without evident cause or regularity, with a maximum temperature of 39.4°C. The patient did not suffer from a cough, expectoration, sore throat, runny nose, chest tightness, chest pain, pant or whole muscle and joint ache. A chest radiograph, obtained in the initial hospital, revealed a fuzzy shadow in the left lower lung (Fig. 1). After intravenous (i.v) treatment with ceftriaxone (2 g/day) and levofloxacin (0.5 g/day) for three days, the fever improved. The patient was admitted to the Jingnan District Centre Hospital of Shanghai (Shanghai, China) with a body temperature of 37.8°C. Emergency blood tests revealed a leukocyte count of 5×109/l (neutrophils, 83.6%) and a C-reactive protein level of 192 mg/l. A chest computed tomography scan (Somatom Definition AS+ 128 Multi-Slice CT Scanner; Siemens, Munich, Germany) revealed a ‘frosted glass’ appearance in both lungs, and a high density shadow was observed in the left lower lobe (Fig. 2). In addition, a bronchiologram revealed inflammation and left lung consolidation. Since the patient was suspected of having pneumonia, the patient was admitted to the Central Hospital of Jingan District for further diagnosis and treatment. This study was conducted in accordance with the Declaration of Helsinki, and with approval from the Ethics Committee of the Central Hospital of Shanghai Jingan District. Written informed consent was obtained from the relatives of the patient.

Bottom Line: No therapeutic effect was observed with anti-infection treatment.Oxygen saturation decreased and gastrointestinal bleeding occurred, with the body temperature fluctuating between 39 and 40°C.Subsequently, clinical death was declared with the patient exhibiting asystole and no spontaneous breathing.

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Jingan District Centre Hospital of Shanghai, Jingan Branch of Huashan Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.

ABSTRACT

A male patient, aged 77 years, was admitted to hospital with the chief complaint of persistent hyperpyrexia that had presented for four days. The patient also suffered from hypoxemia, and a large white shadow in the left lung was observed on a chest radiograph, indicating inflammation. No therapeutic effect was observed with anti-infection treatment. The patient admitted a history of direct contact with live chickens two weeks prior to hospital admission. The day after admission to the Jingnan District Centre Hospital of Shanghai (Shanghai, China), the patient was diagnosed with severe H7N9 avian influenza infection by nasopharyngeal swab and blood sampling detection. Although the patient received anti-infective drugs, intubated assisted ventilation and circulation support, the condition of the patient continued to rapidly deteriorate. Oxygen saturation decreased and gastrointestinal bleeding occurred, with the body temperature fluctuating between 39 and 40°C. By day 6 after admission, the patient presented with circulatory failure, with liver and renal failure. On day 7, the blood pressure of the patient was unable to be measured, and the patient was diagnosed with multiple organ dysfunction. Subsequently, clinical death was declared with the patient exhibiting asystole and no spontaneous breathing.

No MeSH data available.


Related in: MedlinePlus