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Epidemiological, clinical and laboratorial profile of renal amyloidosis: a 12-year retrospective study of 37 cases.

da Fonseca EO, Filho PJ, da Silva LE, Caldas ML - J Nephropathol (2015)

Bottom Line: Hematuria was present in 75% of patients.Hypertension was reported in 34% of patients.Acute renal failure, occurred in about 10% of patients, and chronic loss of renal function was present in about 5% at diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, Brazil.

ABSTRACT

Background: Renal amyloidosis is one of the main differential diagnoses in the investigation of nephrotic proteinuria in adults, especially elderly patients.

Objectives: The aim of this article is to contribute to international research with epidemiologic data of renal amyloidosis, given the lack of uniformity described in the literature.

Patients and methods: A retrospective study of 37 cases of renal amyloidosis diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data.

Results: Subjects aged between 32 and 80 years. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non-AL) renal amyloidosis and 16 (43.2%) as light chain amyloidosis (AL). There was seen an increase in number of both AL and non-AL cases, with a slight predominance in non-AL. The mean 24-hour proteinuria was 5839.0 mg/day. Hematuria was present in 75% of patients. Hypertension was reported in 34% of patients. Acute renal failure, occurred in about 10% of patients, and chronic loss of renal function was present in about 5% at diagnosis.

Conclusions: Renal amyloidosis is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of proteinuria or nephrotic syndrome in elderly patients should always prompt the suspicion of renal amyloidosis and is a formal indication of renal biopsy.

No MeSH data available.


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Mentions: From 2000 to 2011, 37 cases of renal amyloidosis were diagnosed by needle biopsy from a total of 1609 biopsies, corresponding to 2,3%. Eighteen of the selected patients were females and 19 males, with a larger number of cases in recent years, as seen in Figure 1. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non-AL) renal amyloidosis and 16 (43.2%) as light chain (AL) amyloidosis. There was an increase in the number of both AL and non-AL cases, with a slight predominance in non-AL. The age ranged between 32 and 80 years old, mean 57 years, with 62.2% of cases over 50 years. The average age among non-AL cases was 57.9 years and in AL cases it was 56.6 years. Frequency of different types of amyloidosis according to age distribution is reported in Figure 2: 2 patients aged between 30 and 39 years; 9 between 40 and 49 years; 9 between 50 and 59 years; 12 between 60 and 69 years, 4 between 70 and 79 years; and 1 patient with 80 years. There were 12 female patients with non-AL, 10 male with non-AL, 6 female with AL and 9 male with AL amyloidosis. As far as gender is concerned, females exhibited a similar predisposition when compared with males in our study (48.6% of the cases were from female patients and 51.4% from males).


Epidemiological, clinical and laboratorial profile of renal amyloidosis: a 12-year retrospective study of 37 cases.

da Fonseca EO, Filho PJ, da Silva LE, Caldas ML - J Nephropathol (2015)

© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4316584&req=5

Mentions: From 2000 to 2011, 37 cases of renal amyloidosis were diagnosed by needle biopsy from a total of 1609 biopsies, corresponding to 2,3%. Eighteen of the selected patients were females and 19 males, with a larger number of cases in recent years, as seen in Figure 1. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non-AL) renal amyloidosis and 16 (43.2%) as light chain (AL) amyloidosis. There was an increase in the number of both AL and non-AL cases, with a slight predominance in non-AL. The age ranged between 32 and 80 years old, mean 57 years, with 62.2% of cases over 50 years. The average age among non-AL cases was 57.9 years and in AL cases it was 56.6 years. Frequency of different types of amyloidosis according to age distribution is reported in Figure 2: 2 patients aged between 30 and 39 years; 9 between 40 and 49 years; 9 between 50 and 59 years; 12 between 60 and 69 years, 4 between 70 and 79 years; and 1 patient with 80 years. There were 12 female patients with non-AL, 10 male with non-AL, 6 female with AL and 9 male with AL amyloidosis. As far as gender is concerned, females exhibited a similar predisposition when compared with males in our study (48.6% of the cases were from female patients and 51.4% from males).

Bottom Line: Hematuria was present in 75% of patients.Hypertension was reported in 34% of patients.Acute renal failure, occurred in about 10% of patients, and chronic loss of renal function was present in about 5% at diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Hospital Universitario Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, Brazil.

ABSTRACT

Background: Renal amyloidosis is one of the main differential diagnoses in the investigation of nephrotic proteinuria in adults, especially elderly patients.

Objectives: The aim of this article is to contribute to international research with epidemiologic data of renal amyloidosis, given the lack of uniformity described in the literature.

Patients and methods: A retrospective study of 37 cases of renal amyloidosis diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data.

Results: Subjects aged between 32 and 80 years. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non-AL) renal amyloidosis and 16 (43.2%) as light chain amyloidosis (AL). There was seen an increase in number of both AL and non-AL cases, with a slight predominance in non-AL. The mean 24-hour proteinuria was 5839.0 mg/day. Hematuria was present in 75% of patients. Hypertension was reported in 34% of patients. Acute renal failure, occurred in about 10% of patients, and chronic loss of renal function was present in about 5% at diagnosis.

Conclusions: Renal amyloidosis is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of proteinuria or nephrotic syndrome in elderly patients should always prompt the suspicion of renal amyloidosis and is a formal indication of renal biopsy.

No MeSH data available.


Related in: MedlinePlus