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Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus.

Kim SH, Jung IA, Jeon YJ, Cho WK, Cho KS, Park SH, Jung MH, Suh BK - Ann Pediatr Endocrinol Metab (2014)

Bottom Line: This cross-sectional study included 29 Korean young adults and adolescents with T1DM.The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female.HbA1c levels were positively correlated with TC (P=0.03, R (2)=0.156) and TG (P=0.005, R (2)=0.261).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Purpose: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM).

Methods: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis.

Results: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R (2)=0.156) and TG (P=0.005, R (2)=0.261).

Conclusion: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.

No MeSH data available.


Related in: MedlinePlus

Correlation between glycemic control parameters and plasma lipid variables is shown. HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
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Figure 2: Correlation between glycemic control parameters and plasma lipid variables is shown. HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

Mentions: The correlation between glycemic control parameters and plasma lipid variables is shown in Fig. 2. A significant positive correlation was found between HbA1c and TC (P=0.03, R2=0.156) and TG (P=0.005, R2=0.261). HbA1c showed no correlation with LDL-C or HDL-C. Multivariate logistic regression analysis indicated that HbA1c was the only independent risk factor for dyslipidemia (adjusted odds ratio, 3.11; 95% confidence interval, 1.35-7.40; P=0.01).


Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus.

Kim SH, Jung IA, Jeon YJ, Cho WK, Cho KS, Park SH, Jung MH, Suh BK - Ann Pediatr Endocrinol Metab (2014)

Correlation between glycemic control parameters and plasma lipid variables is shown. HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4316412&req=5

Figure 2: Correlation between glycemic control parameters and plasma lipid variables is shown. HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglyceride; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
Mentions: The correlation between glycemic control parameters and plasma lipid variables is shown in Fig. 2. A significant positive correlation was found between HbA1c and TC (P=0.03, R2=0.156) and TG (P=0.005, R2=0.261). HbA1c showed no correlation with LDL-C or HDL-C. Multivariate logistic regression analysis indicated that HbA1c was the only independent risk factor for dyslipidemia (adjusted odds ratio, 3.11; 95% confidence interval, 1.35-7.40; P=0.01).

Bottom Line: This cross-sectional study included 29 Korean young adults and adolescents with T1DM.The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female.HbA1c levels were positively correlated with TC (P=0.03, R (2)=0.156) and TG (P=0.005, R (2)=0.261).

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Purpose: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM).

Methods: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis.

Results: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R (2)=0.156) and TG (P=0.005, R (2)=0.261).

Conclusion: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.

No MeSH data available.


Related in: MedlinePlus