Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study.
Bottom Line: However, to date the long-term associations between diet and inflammation have been poorly described.After adjustment for sociodemographic factors, health behaviors, and health status, participants who maintained a high AHEI score (ie, a healthy diet, n = 1736, 37.7%) and those who improved this score over time (n = 681, 14.8%) showed significantly lower mean levels of interleukin-6 (1.84 pg/mL, 95% confidence interval [CI], 1.71-1.98 and 1.84 pg/mL, 95% CI, 1.70-1.99, respectively) than those who had a low AHEI score (n = 1594, 34.6%) over the 6-year exposure period (2.01 pg/mL, 95% CI, 1.87-2.17).These data suggest that maintaining and improving adherence to healthy dietary recommendations may reduce the risk of long-term inflammation.
Affiliation: Inserm U710, Montpellier, F-34000, France; University Montpellier II, Montpellier, France; EPHE, Paris, France; Department of Epidemiology and Public Health, University College London, London, United Kingdom. Electronic address: firstname.lastname@example.org.Show MeSH
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Mentions: The percentage difference in the average of 2 measures of IL-6 according to the AHEI change categories are shown in Table 2 and Figure 2. Compared with participants who maintained a lower AHEI score (n = 1591, 34.6%) over the 6-year exposure period, those who improved their adherence to AHEI guidelines (n = 681, 14.8%) and those who maintained high AHEI scores (n = 1736, 37.7%) over this period had lower average IL-6 values after adjustment for age, sex, ethnicity, socioeconomic status, and use of anti-inflammatory drugs. Further adjustment slightly attenuated but did not remove these associations (Table 2). Among the 2275 participants who had a lower AHEI score in 1991/1993, each 10-point increase in AHEI score over the 6-year exposure period was associated with a reduction of 4.2% in subsequent average levels of IL-6 (P < .001) (results not shown).
Affiliation: Inserm U710, Montpellier, F-34000, France; University Montpellier II, Montpellier, France; EPHE, Paris, France; Department of Epidemiology and Public Health, University College London, London, United Kingdom. Electronic address: email@example.com.