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Breast cancer in women younger than 30 years: prevalence rate and imaging findings in a symptomatic population.

Makanjuola D, Alkushi A, Alzaid M, Abukhair O, Al Tahan F, Alhadab A - Pan Afr Med J (2014)

Bottom Line: Only 2 of the 17 had first-degree family history.The youngest was 17 years old.A prevalence rate of 3.5 per 1000 primary cancer occurred in the symptomatic population studied and 4 in every 100 primary cancer diagnosed in the unit occurred in women younger than 30 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging King Abdulaziz Medical City for National Guard, PO Box 22490 Riyadh, Saudi Arabia.

ABSTRACT

Introduction: To identify the prevalence rate of primary breast cancer in women younger than 30 years of age in a symptomatic population in Riyadh, Kingdom of Saudi Arabia. To analyze the imaging pattern and possible risk factors in cases with cancer. Breast cancer in this age group is generally rare and not clearly understood.

Methods: At King Abdulaziz Medical City for National Guard, Riyadh, a retrospective 5-year (January 2006 to December 2010) data was collected from the Medical Imaging departmental records on breast imaging. Patients younger than 30 years of age were identified including those with breast cancer. The clinical presentation, risk factors, imaging findings and final outcomes were analyzed in a descriptive way. The total number of patients diagnosed with primary breast cancer was recorded.

Results: Seventeen out of a total of 4873 patients younger than 30 years examined had primary breast cancer constituting a rate of 3.5 per 1000 symptomatic patients. The age range was 17 to 29 with mean of 27. The total number of patients with primary breast cancer diagnosed during that period was 413 making a percentage of 4.1% (17 out of 413) in those younger than 30 years. First presentation with a palpable mass and imaging findings of unequivocal category 5 of Breast Imaging Reporting and Data System (BI-RADS) occurred in all. Eight patients had stage I and II while nine had stage III and IV cancers. Only 2 of the 17 had first-degree family history. The youngest was 17 years old.

Conclusion: A prevalence rate of 3.5 per 1000 primary cancer occurred in the symptomatic population studied and 4 in every 100 primary cancer diagnosed in the unit occurred in women younger than 30 years. First presentation, low family trait and typical imaging features of malignancy was found in all cases.

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Ultrasound imaging confirms the microlobulated mass with posterior shadowing in the right breast revealing malignant characteristics (arrowed)
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Figure 0006: Ultrasound imaging confirms the microlobulated mass with posterior shadowing in the right breast revealing malignant characteristics (arrowed)

Mentions: All the cases (N=17) were symptomatic and presented with palpable masses or obvious advanced unilateral changes. The lesions were identified in both ultrasound and mammograms and classified as BI-RADS category 5. Mammograms were obtained in this age group due to the suspicion of cancer. Five out of the 17 had stage 4 with near total involvement of the breast. Four had stage 3 with lesions between 5-9 cm. Stage 2 occurred in 5 cases where lesions were seen 2-5 cm. Stage 1 in 3 cases with less than 2 cm width. Figure 3A and Figure 4 show the smallest lesion in the study which was located deep in the breast. Three patients were pregnant at presentation and one of them had metastatic disease at presentation while the other two had stage 2 and 3 axillary node positive disease. Histopathological analysis revealed all had invasive ductal carcinoma except the youngest 17 years old who had secretory carcinoma (Figure 5, Figure 6, Figure 7). All except the 17-year-old patient had nuclear grade 3 tumors, 13 of the 17 had hormone receptor-negative cancers, 12 of the 17 had positive axillary node biopsy. All those with stage 1 and two of those with stage 2 had node-free disease. In the final outcome, 7 of the 17 had mastectomy, 6 patients had lumpectomy and 3 patients have expired. These three patients were those with metastatic disease identified by CT and bone scan at presentation.


Breast cancer in women younger than 30 years: prevalence rate and imaging findings in a symptomatic population.

Makanjuola D, Alkushi A, Alzaid M, Abukhair O, Al Tahan F, Alhadab A - Pan Afr Med J (2014)

Ultrasound imaging confirms the microlobulated mass with posterior shadowing in the right breast revealing malignant characteristics (arrowed)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4314149&req=5

Figure 0006: Ultrasound imaging confirms the microlobulated mass with posterior shadowing in the right breast revealing malignant characteristics (arrowed)
Mentions: All the cases (N=17) were symptomatic and presented with palpable masses or obvious advanced unilateral changes. The lesions were identified in both ultrasound and mammograms and classified as BI-RADS category 5. Mammograms were obtained in this age group due to the suspicion of cancer. Five out of the 17 had stage 4 with near total involvement of the breast. Four had stage 3 with lesions between 5-9 cm. Stage 2 occurred in 5 cases where lesions were seen 2-5 cm. Stage 1 in 3 cases with less than 2 cm width. Figure 3A and Figure 4 show the smallest lesion in the study which was located deep in the breast. Three patients were pregnant at presentation and one of them had metastatic disease at presentation while the other two had stage 2 and 3 axillary node positive disease. Histopathological analysis revealed all had invasive ductal carcinoma except the youngest 17 years old who had secretory carcinoma (Figure 5, Figure 6, Figure 7). All except the 17-year-old patient had nuclear grade 3 tumors, 13 of the 17 had hormone receptor-negative cancers, 12 of the 17 had positive axillary node biopsy. All those with stage 1 and two of those with stage 2 had node-free disease. In the final outcome, 7 of the 17 had mastectomy, 6 patients had lumpectomy and 3 patients have expired. These three patients were those with metastatic disease identified by CT and bone scan at presentation.

Bottom Line: Only 2 of the 17 had first-degree family history.The youngest was 17 years old.A prevalence rate of 3.5 per 1000 primary cancer occurred in the symptomatic population studied and 4 in every 100 primary cancer diagnosed in the unit occurred in women younger than 30 years.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Imaging King Abdulaziz Medical City for National Guard, PO Box 22490 Riyadh, Saudi Arabia.

ABSTRACT

Introduction: To identify the prevalence rate of primary breast cancer in women younger than 30 years of age in a symptomatic population in Riyadh, Kingdom of Saudi Arabia. To analyze the imaging pattern and possible risk factors in cases with cancer. Breast cancer in this age group is generally rare and not clearly understood.

Methods: At King Abdulaziz Medical City for National Guard, Riyadh, a retrospective 5-year (January 2006 to December 2010) data was collected from the Medical Imaging departmental records on breast imaging. Patients younger than 30 years of age were identified including those with breast cancer. The clinical presentation, risk factors, imaging findings and final outcomes were analyzed in a descriptive way. The total number of patients diagnosed with primary breast cancer was recorded.

Results: Seventeen out of a total of 4873 patients younger than 30 years examined had primary breast cancer constituting a rate of 3.5 per 1000 symptomatic patients. The age range was 17 to 29 with mean of 27. The total number of patients with primary breast cancer diagnosed during that period was 413 making a percentage of 4.1% (17 out of 413) in those younger than 30 years. First presentation with a palpable mass and imaging findings of unequivocal category 5 of Breast Imaging Reporting and Data System (BI-RADS) occurred in all. Eight patients had stage I and II while nine had stage III and IV cancers. Only 2 of the 17 had first-degree family history. The youngest was 17 years old.

Conclusion: A prevalence rate of 3.5 per 1000 primary cancer occurred in the symptomatic population studied and 4 in every 100 primary cancer diagnosed in the unit occurred in women younger than 30 years. First presentation, low family trait and typical imaging features of malignancy was found in all cases.

Show MeSH
Related in: MedlinePlus