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Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension.

Cho SK, Cho SK, Kim KH, Cho JY, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC - Korean Circ J (2015)

Bottom Line: Pulse wave analysis (PWA) was compared.Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group.However, PWV might be a better marker for old patients with HT.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Christian Hospital, Gwangju, Korea.

ABSTRACT

Background and objectives: To investigate the impact of age on arterial stiffness and blood pressure (BP) variables in newly diagnosed untreated hypertension (HT).

Subjects and methods: A total of 144 patients with newly diagnosed untreated HT were divided into two groups: young group (age ≤50 years, n=71), and old group (age >50 years, n=73). BP variables were measured on office or 24 hours ambulatory BP monitoring (ABPM). Parameters of arterial stiffness were measured on pulse wave velocity (PWV). Pulse wave analysis (PWA) was compared.

Results: Although office BP and pulse pressure (PP) were significantly (p<0.05) higher in the young group than in the old group, BP and PP on ABPM were not significantly different. Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group. Age showed significant positive correlation with both PWV and PWA variables in the young group with HT. However, age only showed significant positive correlation with PWV in the old group with HT. In the young group with HT, PWA variable showed better correlation with age than PWV.

Conclusion: Considering BP levels on ABPM, office BP is prone to be overestimated in young patients with HT. Parameters of arterial stiffness measured by PWV and PWA were more affected by age rather than by BP level in patients with HT. Therefore, PWA variable might be a more sensitive marker of arterial stiffness in young patients with HT. However, PWV might be a better marker for old patients with HT.

No MeSH data available.


Related in: MedlinePlus

Correlation of the difference of systolic blood pressure (ΔSBP) on office or 24 hours ambulatory blood pressure measurements with age in patients with hypertension. Age showed significant negative correlation with ΔSBP.
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Figure 1: Correlation of the difference of systolic blood pressure (ΔSBP) on office or 24 hours ambulatory blood pressure measurements with age in patients with hypertension. Age showed significant negative correlation with ΔSBP.

Mentions: The differences of BP measurements between the two groups were summarized in Table 2. Office systolic and diastolic BP and PP were significantly (p<0.05) higher in the young group than in the old group. However, BP measurements on 24 hours ABPM were not significantly different between the groups. Overall, the difference of systolic BP between office and 24 hours ABPM (office systolic BP-systolic BP on 24 ABPM) showed significant negative correlation with age (r=-0.320, p<0.001) (Fig. 1).


Effects of age on arterial stiffness and blood pressure variables in patients with newly diagnosed untreated hypertension.

Cho SK, Cho SK, Kim KH, Cho JY, Yoon HJ, Yoon NS, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC - Korean Circ J (2015)

Correlation of the difference of systolic blood pressure (ΔSBP) on office or 24 hours ambulatory blood pressure measurements with age in patients with hypertension. Age showed significant negative correlation with ΔSBP.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310979&req=5

Figure 1: Correlation of the difference of systolic blood pressure (ΔSBP) on office or 24 hours ambulatory blood pressure measurements with age in patients with hypertension. Age showed significant negative correlation with ΔSBP.
Mentions: The differences of BP measurements between the two groups were summarized in Table 2. Office systolic and diastolic BP and PP were significantly (p<0.05) higher in the young group than in the old group. However, BP measurements on 24 hours ABPM were not significantly different between the groups. Overall, the difference of systolic BP between office and 24 hours ABPM (office systolic BP-systolic BP on 24 ABPM) showed significant negative correlation with age (r=-0.320, p<0.001) (Fig. 1).

Bottom Line: Pulse wave analysis (PWA) was compared.Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group.However, PWV might be a better marker for old patients with HT.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Christian Hospital, Gwangju, Korea.

ABSTRACT

Background and objectives: To investigate the impact of age on arterial stiffness and blood pressure (BP) variables in newly diagnosed untreated hypertension (HT).

Subjects and methods: A total of 144 patients with newly diagnosed untreated HT were divided into two groups: young group (age ≤50 years, n=71), and old group (age >50 years, n=73). BP variables were measured on office or 24 hours ambulatory BP monitoring (ABPM). Parameters of arterial stiffness were measured on pulse wave velocity (PWV). Pulse wave analysis (PWA) was compared.

Results: Although office BP and pulse pressure (PP) were significantly (p<0.05) higher in the young group than in the old group, BP and PP on ABPM were not significantly different. Central systolic BP and PP, augmentation pressure, augmentation index on PWA, and PWV were significantly higher or faster in the old group compared to that in the young group. Age showed significant positive correlation with both PWV and PWA variables in the young group with HT. However, age only showed significant positive correlation with PWV in the old group with HT. In the young group with HT, PWA variable showed better correlation with age than PWV.

Conclusion: Considering BP levels on ABPM, office BP is prone to be overestimated in young patients with HT. Parameters of arterial stiffness measured by PWV and PWA were more affected by age rather than by BP level in patients with HT. Therefore, PWA variable might be a more sensitive marker of arterial stiffness in young patients with HT. However, PWV might be a better marker for old patients with HT.

No MeSH data available.


Related in: MedlinePlus