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Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis.

Lee JS, Shin JH, Choi BS - J. Korean Med. Sci. (2015)

Bottom Line: Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung.The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003).Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026).

View Article: PubMed Central - PubMed

Affiliation: Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea.

ABSTRACT
Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1α (MIP-α), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.

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Serum levels of cytokines stratified by ILO category in the subjects without PMF. The mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P = 0.006) and with ILO category I (P = 0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P = 0.031).
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Figure 1: Serum levels of cytokines stratified by ILO category in the subjects without PMF. The mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P = 0.006) and with ILO category I (P = 0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P = 0.031).

Mentions: In the subjects without PMF, the mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P=0.006) and with ILO category I (P=0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P=0.031). Although mean level of ICAM-1 did not show significant differences among the subjects stratified by ILO category, the mean ICAM-1 level of ILO category II or III subjects tended to be higher than that of ILO category 0 (P=0.050) (Fig. 1).


Serum levels of IL-8 and ICAM-1 as biomarkers for progressive massive fibrosis in coal workers' pneumoconiosis.

Lee JS, Shin JH, Choi BS - J. Korean Med. Sci. (2015)

Serum levels of cytokines stratified by ILO category in the subjects without PMF. The mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P = 0.006) and with ILO category I (P = 0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P = 0.031).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310938&req=5

Figure 1: Serum levels of cytokines stratified by ILO category in the subjects without PMF. The mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P = 0.006) and with ILO category I (P = 0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P = 0.031).
Mentions: In the subjects without PMF, the mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P=0.006) and with ILO category I (P=0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P=0.031). Although mean level of ICAM-1 did not show significant differences among the subjects stratified by ILO category, the mean ICAM-1 level of ILO category II or III subjects tended to be higher than that of ILO category 0 (P=0.050) (Fig. 1).

Bottom Line: Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung.The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003).Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026).

View Article: PubMed Central - PubMed

Affiliation: Occupational Lung Diseases Institute, Korea Workers' Compensation & Welfare Service, Incheon, Korea.

ABSTRACT
Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1α (MIP-α), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.

Show MeSH
Related in: MedlinePlus