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The short-term effects of risperidone-induced hyperprolactinemia on lipid metabolism in drug-naïve children and adolescents.

Park EJ, Park YM - Psychiatry Investig (2015)

Bottom Line: The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001).In young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range.Further investigation is needed around this issue.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.

ABSTRACT

Objective: The present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone.

Methods: Twenty-five children and adolescents [aged 7-18 years, 12.1±3.3 years (mean±SD); 19 boys and 6 girls] who had been taking risperidone for at least 3 months were enrolled. The following blood parameters were measured: serum levels of prolactin, thyroid hormones, alanine transaminase (ALT), sex hormones, lipids.

Results: The median risperidone dosage was 1.55 mg/day (SD 1.14 mg/day, range 0.25-4.00 mg/day). The prolactin level (33.65±16.71 ng/mL, range 5.8-68.3 ng/mL) was higher than normal, and was elevated (≥15 ng/mL in male, ≥23.3 ng/mL in female) in about 84% of the patients. The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001). The TG/HDL ratio was higher in the group with higher prolactin levels (i.e., ≥30 ng/mL), and hence might be a useful marker of insulin resistance.

Conclusion: In young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range. Further investigation is needed around this issue. Serum prolactin assessment is recommended for children and adolescents taking risperidone.

No MeSH data available.


Related in: MedlinePlus

TG/HDL ratio according to low and high prolactin levels (dichotomized at prolactin level 30 ng/mL). TG: triglyceride, HDL: high-density lipoprotein.
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Figure 3: TG/HDL ratio according to low and high prolactin levels (dichotomized at prolactin level 30 ng/mL). TG: triglyceride, HDL: high-density lipoprotein.

Mentions: The TG/HDL ratio was higher in the group of patients with particularly high prolactin levels (i.e., ≥30 ng/mL) after adjusting for age and BMI (p=0.028) (Figure 3, Table 4).


The short-term effects of risperidone-induced hyperprolactinemia on lipid metabolism in drug-naïve children and adolescents.

Park EJ, Park YM - Psychiatry Investig (2015)

TG/HDL ratio according to low and high prolactin levels (dichotomized at prolactin level 30 ng/mL). TG: triglyceride, HDL: high-density lipoprotein.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310921&req=5

Figure 3: TG/HDL ratio according to low and high prolactin levels (dichotomized at prolactin level 30 ng/mL). TG: triglyceride, HDL: high-density lipoprotein.
Mentions: The TG/HDL ratio was higher in the group of patients with particularly high prolactin levels (i.e., ≥30 ng/mL) after adjusting for age and BMI (p=0.028) (Figure 3, Table 4).

Bottom Line: The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001).In young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range.Further investigation is needed around this issue.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.

ABSTRACT

Objective: The present cross-sectional study was designed to assess the risk of elevated prolactin levels and other hormonal or metabolic changes in children and adolescents taking risperidone.

Methods: Twenty-five children and adolescents [aged 7-18 years, 12.1±3.3 years (mean±SD); 19 boys and 6 girls] who had been taking risperidone for at least 3 months were enrolled. The following blood parameters were measured: serum levels of prolactin, thyroid hormones, alanine transaminase (ALT), sex hormones, lipids.

Results: The median risperidone dosage was 1.55 mg/day (SD 1.14 mg/day, range 0.25-4.00 mg/day). The prolactin level (33.65±16.71 ng/mL, range 5.8-68.3 ng/mL) was higher than normal, and was elevated (≥15 ng/mL in male, ≥23.3 ng/mL in female) in about 84% of the patients. The dosage of risperidone was positively correlated with serum prolactin level (r=0.767, p<0.001). The TG/HDL ratio was higher in the group with higher prolactin levels (i.e., ≥30 ng/mL), and hence might be a useful marker of insulin resistance.

Conclusion: In young patients taking risperidone, a high serum prolactin level may influence lipid metabolism, even when cholesterol levels are within the normal range. Further investigation is needed around this issue. Serum prolactin assessment is recommended for children and adolescents taking risperidone.

No MeSH data available.


Related in: MedlinePlus