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Gene interactions and structural brain change in early-onset Alzheimer's disease subjects using the pipeline environment.

Moon SW, Dinov ID, Zamanyan A, Shi R, Genco A, Hobel S, Thompson PM, Toga AW, Alzheimer's Disease Neuroimaging Initiative (ADN - Psychiatry Investig (2015)

Bottom Line: For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume).For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area).However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Konkuk University School of Medicine, Chungju, Republic of Korea.

ABSTRACT

Objective: This article investigates subjects aged 55 to 65 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) cognitive impairment using neuroimaging and genetics biomarkers.

Methods: Nine of the subjects had EO-AD (Alzheimer's disease) and 27 had EO-MCI (mild cognitive impairment). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers.

Results: We identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between rs7718456 and L_hippocampus (volume), and between rs7718456 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area).

Conclusion: We observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.

No MeSH data available.


Related in: MedlinePlus

A: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_gyrus (volume) (p=0.000086). B: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_ gyrus (volume) (p=0.000086). C: There were several significant results (p<0.009) such as between rs12101936 and R_inf_occipital_gyrus (curvedness) (p=0.00138); rs16964473 and L_rectus gyrus (surface area) (p=0.00235); rs12972537 and L_rectus_gyrus (surface area) (p=0.00235); rs7718456 and R_hippocampus (volume) (p=0.00272); and rs1266320 and R_hippocampus (volume) (p=0.00275).
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Figure 7: A: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_gyrus (volume) (p=0.000086). B: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_ gyrus (volume) (p=0.000086). C: There were several significant results (p<0.009) such as between rs12101936 and R_inf_occipital_gyrus (curvedness) (p=0.00138); rs16964473 and L_rectus gyrus (surface area) (p=0.00235); rs12972537 and L_rectus_gyrus (surface area) (p=0.00235); rs7718456 and R_hippocampus (volume) (p=0.00272); and rs1266320 and R_hippocampus (volume) (p=0.00275).

Mentions: The genetic association study between the 20 SNPs and the 15 neuroimaging phenotypes are shown in Figure 7. The Pipeline workflow used to compute these SNP-imaging biomarker associations is shown in Figure 3B.


Gene interactions and structural brain change in early-onset Alzheimer's disease subjects using the pipeline environment.

Moon SW, Dinov ID, Zamanyan A, Shi R, Genco A, Hobel S, Thompson PM, Toga AW, Alzheimer's Disease Neuroimaging Initiative (ADN - Psychiatry Investig (2015)

A: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_gyrus (volume) (p=0.000086). B: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_ gyrus (volume) (p=0.000086). C: There were several significant results (p<0.009) such as between rs12101936 and R_inf_occipital_gyrus (curvedness) (p=0.00138); rs16964473 and L_rectus gyrus (surface area) (p=0.00235); rs12972537 and L_rectus_gyrus (surface area) (p=0.00235); rs7718456 and R_hippocampus (volume) (p=0.00272); and rs1266320 and R_hippocampus (volume) (p=0.00275).
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Figure 7: A: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_gyrus (volume) (p=0.000086). B: There were several significant results (p<0.001) such as between rs17029131 and L_Precuneus (volume) (p=0.000000008832); rs6446443 and R_superior_frontal_gyrus (volume) (p=0.000005269); rs9377090 and R_Hippocampus (volume) (p=0.000006); rs7718456 and L_Cuneus (shape index) (p=0.000024); and rs7718456 and R_superior_temporal_ gyrus (volume) (p=0.000086). C: There were several significant results (p<0.009) such as between rs12101936 and R_inf_occipital_gyrus (curvedness) (p=0.00138); rs16964473 and L_rectus gyrus (surface area) (p=0.00235); rs12972537 and L_rectus_gyrus (surface area) (p=0.00235); rs7718456 and R_hippocampus (volume) (p=0.00272); and rs1266320 and R_hippocampus (volume) (p=0.00275).
Mentions: The genetic association study between the 20 SNPs and the 15 neuroimaging phenotypes are shown in Figure 7. The Pipeline workflow used to compute these SNP-imaging biomarker associations is shown in Figure 3B.

Bottom Line: For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume).For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area).However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Konkuk University School of Medicine, Chungju, Republic of Korea.

ABSTRACT

Objective: This article investigates subjects aged 55 to 65 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to broaden our understanding of early-onset (EO) cognitive impairment using neuroimaging and genetics biomarkers.

Methods: Nine of the subjects had EO-AD (Alzheimer's disease) and 27 had EO-MCI (mild cognitive impairment). The 15 most important neuroimaging markers were extracted with the Global Shape Analysis (GSA) Pipeline workflow. The 20 most significant single nucleotide polymorphisms (SNPs) were chosen and were associated with specific neuroimaging biomarkers.

Results: We identified associations between the neuroimaging phenotypes and genotypes for a total of 36 subjects. Our results for all the subjects taken together showed the most significant associations between rs7718456 and L_hippocampus (volume), and between rs7718456 and R_hippocampus (volume). For the 27 MCI subjects, we found the most significant associations between rs6446443 and R_superior_frontal_gyrus (volume), and between rs17029131 and L_Precuneus (volume). For the nine AD subjects, we found the most significant associations between rs16964473 and L_rectus gyrus (surface area), and between rs12972537 and L_rectus_gyrus (surface area).

Conclusion: We observed significant correlations between the SNPs and the neuroimaging phenotypes in the 36 EO subjects in terms of neuroimaging genetics. However, larger sample sizes are needed to ensure that the effects will be detectable for a reasonable false-positive error rate using the GSA and Plink Pipeline workflows.

No MeSH data available.


Related in: MedlinePlus