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Pain and depression: a neurobiological perspective of their relationship.

Han C, Pae CU - Psychiatry Investig (2015)

Bottom Line: The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression.With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches.This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.

ABSTRACT
Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

No MeSH data available.


Related in: MedlinePlus

The association of pain and depression in pathophysiology and symptomatology.
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Figure 2: The association of pain and depression in pathophysiology and symptomatology.

Mentions: Contemporary findings suggest that understanding the brain is a critical and indispensable component of pain and depression research involved in explaining the ways in which biological, psychological, behavioural and social factors influence both pain and depression, and offers a way to the optimal therapeutic approach (Figure 2).24 Psychosocial and behavioural factors play a significant role in the experience, maintenance, and exacerbation of pain.37 CBT alone or within the context of an interdisciplinary pain rehabilitation program has the greatest empirical evidence for success.37 As none of the most commonly prescribed treatment regimens are sufficient to eliminate pain, a more realistic approach will likely combine pharmacological, physical, and psychological components tailored to each patient's needs.59


Pain and depression: a neurobiological perspective of their relationship.

Han C, Pae CU - Psychiatry Investig (2015)

The association of pain and depression in pathophysiology and symptomatology.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310906&req=5

Figure 2: The association of pain and depression in pathophysiology and symptomatology.
Mentions: Contemporary findings suggest that understanding the brain is a critical and indispensable component of pain and depression research involved in explaining the ways in which biological, psychological, behavioural and social factors influence both pain and depression, and offers a way to the optimal therapeutic approach (Figure 2).24 Psychosocial and behavioural factors play a significant role in the experience, maintenance, and exacerbation of pain.37 CBT alone or within the context of an interdisciplinary pain rehabilitation program has the greatest empirical evidence for success.37 As none of the most commonly prescribed treatment regimens are sufficient to eliminate pain, a more realistic approach will likely combine pharmacological, physical, and psychological components tailored to each patient's needs.59

Bottom Line: The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression.With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches.This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.

ABSTRACT
Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.

No MeSH data available.


Related in: MedlinePlus