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Diagnostic significance of biopsies in renal masses.

Dogan B, Altinova S, Ozdemir AT, Ozcan MF, Asil E, Akbulut Z, Balbay MD - Cent European J Urol (2014)

Bottom Line: Sensitivity and specificity in differentiating malignant lesions were 93% and 87%, and 90% and 93% for peripheral and central biopsies, respectively.Positive and negative predictive values were 97% and 68%, and 98% and 64% for peripheral biopsies and central biopsies, respectively.Kidney biopsies can be performed in suspicious renal masses of central and peripheral biopsies with similar efficacy.

View Article: PubMed Central - PubMed

Affiliation: Manisa State Hospital, Manisa, Turkey.

ABSTRACT

Introduction: We investigated the reliability and mapping of percutaneous needle core biopsies in the kidney in histopathological diagnosis of renal masses particularly for those with suspicious radiologic appearance in an attempt to prevent unnecessary nephrectomies.

Material and methods: Overall, 96 cases were included in our study that underwent radical nephrectomy or partial nephrectomy due to renal mass between November 2007 - March 2010. Ex-vivo biopsies 1 cm apart were obtained from the peripheral region of the mass. Additionally, half of these peripheral biopsies were obtained from the central region of the mass. Diagnostic yield of the biopsy cores were correlated. Sensitivity and specificity of peripheral and central biopsies in differentiating benign and malignant tissues were calculated.

Results: Sensitivity and specificity in differentiating malignant lesions were 93% and 87%, and 90% and 93% for peripheral and central biopsies, respectively. Positive and negative predictive values were 97% and 68%, and 98% and 64% for peripheral biopsies and central biopsies, respectively. Hazard ratio for cigarette smoking and presence of necrosis on CT scans were 4.76 (CI 1, 6-14.3; p = 0.04) and 3.32 (CI 1,2-9.2; p = 0.017) and 3.71 (CI 1.3-10.7; p = 0.013) and 3,51 (CI 1.3-9.6; p = 0.012) for peripheral and central biopsies, respectively.

Conclusions: Kidney biopsies can be performed in suspicious renal masses of central and peripheral biopsies with similar efficacy.

No MeSH data available.


Related in: MedlinePlus

The samples were collected by 1 cm intervals in the periphery and in the center and by half the number of biopsies taken from periphery.
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Figure 0001: The samples were collected by 1 cm intervals in the periphery and in the center and by half the number of biopsies taken from periphery.

Mentions: Needle biopsy samples were obtained ex vivo from specimens of the patients after partial or radical nephrectomy, with an 18–gauge automatic biopsy gun (GTA International Medical Devices). The samples were collected at 1–cm intervals at the periphery through the long axis of the mass as detected by preoperative CT; in the centre, samples were taken of half the number of biopsies taken from the periphery (Figure 1). The biopsy specimens were evaluated by a single pathologist who was unaware of the patient's characteristics or the final histological diagnosis of each pathological specimen. The pathological findings of each biopsy specimen were compared with the pathologic findings of the excised specimen, and correlated with the demographic data of the patient and the mass characteristics as defined by imaging techniques.


Diagnostic significance of biopsies in renal masses.

Dogan B, Altinova S, Ozdemir AT, Ozcan MF, Asil E, Akbulut Z, Balbay MD - Cent European J Urol (2014)

The samples were collected by 1 cm intervals in the periphery and in the center and by half the number of biopsies taken from periphery.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310894&req=5

Figure 0001: The samples were collected by 1 cm intervals in the periphery and in the center and by half the number of biopsies taken from periphery.
Mentions: Needle biopsy samples were obtained ex vivo from specimens of the patients after partial or radical nephrectomy, with an 18–gauge automatic biopsy gun (GTA International Medical Devices). The samples were collected at 1–cm intervals at the periphery through the long axis of the mass as detected by preoperative CT; in the centre, samples were taken of half the number of biopsies taken from the periphery (Figure 1). The biopsy specimens were evaluated by a single pathologist who was unaware of the patient's characteristics or the final histological diagnosis of each pathological specimen. The pathological findings of each biopsy specimen were compared with the pathologic findings of the excised specimen, and correlated with the demographic data of the patient and the mass characteristics as defined by imaging techniques.

Bottom Line: Sensitivity and specificity in differentiating malignant lesions were 93% and 87%, and 90% and 93% for peripheral and central biopsies, respectively.Positive and negative predictive values were 97% and 68%, and 98% and 64% for peripheral biopsies and central biopsies, respectively.Kidney biopsies can be performed in suspicious renal masses of central and peripheral biopsies with similar efficacy.

View Article: PubMed Central - PubMed

Affiliation: Manisa State Hospital, Manisa, Turkey.

ABSTRACT

Introduction: We investigated the reliability and mapping of percutaneous needle core biopsies in the kidney in histopathological diagnosis of renal masses particularly for those with suspicious radiologic appearance in an attempt to prevent unnecessary nephrectomies.

Material and methods: Overall, 96 cases were included in our study that underwent radical nephrectomy or partial nephrectomy due to renal mass between November 2007 - March 2010. Ex-vivo biopsies 1 cm apart were obtained from the peripheral region of the mass. Additionally, half of these peripheral biopsies were obtained from the central region of the mass. Diagnostic yield of the biopsy cores were correlated. Sensitivity and specificity of peripheral and central biopsies in differentiating benign and malignant tissues were calculated.

Results: Sensitivity and specificity in differentiating malignant lesions were 93% and 87%, and 90% and 93% for peripheral and central biopsies, respectively. Positive and negative predictive values were 97% and 68%, and 98% and 64% for peripheral biopsies and central biopsies, respectively. Hazard ratio for cigarette smoking and presence of necrosis on CT scans were 4.76 (CI 1, 6-14.3; p = 0.04) and 3.32 (CI 1,2-9.2; p = 0.017) and 3.71 (CI 1.3-10.7; p = 0.013) and 3,51 (CI 1.3-9.6; p = 0.012) for peripheral and central biopsies, respectively.

Conclusions: Kidney biopsies can be performed in suspicious renal masses of central and peripheral biopsies with similar efficacy.

No MeSH data available.


Related in: MedlinePlus