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The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer.

Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K - J Epidemiol (2014)

Bottom Line: The ABO blood group is reported to be associated with the incidence and patient survival for several types of malignancies.A multivariate analysis for overall survival showed the ABO blood group (group A vs. group O: HR 2.47, group AB vs. group O: HR 3.62) to be an independent significant prognostic factor, in addition to age, sex, smoking status, p-stage, and serum CEA level.A multivariate analysis for disease-free survival also showed the ABO blood group to be an independent significant prognostic factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Nagoya University Graduate School of Medicine.

ABSTRACT

Background: The ABO blood group is reported to be associated with the incidence and patient survival for several types of malignancies. We conducted a retrospective study to evaluate the prognostic significance of the ABO blood group in patients with resected non-small cell lung cancer (NSCLC).

Methods: A total of 333 patients (218 men and 115 women) with resected NSCLC were included in this study. In addition to age, sex, smoking status, preoperative serum carcinoembryonic antigen (CEA) level, operative procedure, histology of tumors, pathological stage (p-stage), and adjuvant therapy, the association between the ABO blood group and survival was explored.

Results: The 5-year overall and disease-free survival rates were 83.0% and 71.6% for blood group O, 67.2% and 62.3% for blood group A, 68.8% and 68.8% for blood group B and 69.2% and 65.3% for blood group AB, respectively. A multivariate analysis for overall survival showed the ABO blood group (group A vs. group O: HR 2.47, group AB vs. group O: HR 3.62) to be an independent significant prognostic factor, in addition to age, sex, smoking status, p-stage, and serum CEA level. A multivariate analysis for disease-free survival also showed the ABO blood group to be an independent significant prognostic factor.

Conclusions: The ABO blood group is an independent prognostic factor in patients with resected NSCLC. Studies of other larger cohorts are therefore needed to confirm the relationship between the ABO blood group and the prognosis among patients with resected NSCLC.

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Overall survival curves of all patients (n = 333). The 5-year overall survival rate was 83.6% (95% confidence interval [CI], 75%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in the non-O blood groups (P = 0.016).
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fig01: Overall survival curves of all patients (n = 333). The 5-year overall survival rate was 83.6% (95% confidence interval [CI], 75%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in the non-O blood groups (P = 0.016).

Mentions: There were 108 (32.4%) patients with blood group O, 140 (42.1%) with blood group A, 59 (17.7%) with blood group B, and 26 (7.8%) with blood group AB. The distribution of each blood group was similar to that of the general population in Japan.15 There were significantly more advanced-stage patients in blood group O than in any other group (P = 0.037). The overall survival curves of each blood group are shown in Figure 1. The five-year overall survival (OS) rate was 83.6% (95% CI, 75.0%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in non-O blood groups (P = 0.016). Stratified analysis by p-stage revealed that the association between the ABO blood group and overall survival was similar in each p-stage group.


The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer.

Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F, Nakamura S, Yokoi K - J Epidemiol (2014)

Overall survival curves of all patients (n = 333). The 5-year overall survival rate was 83.6% (95% confidence interval [CI], 75%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in the non-O blood groups (P = 0.016).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310871&req=5

fig01: Overall survival curves of all patients (n = 333). The 5-year overall survival rate was 83.6% (95% confidence interval [CI], 75%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in the non-O blood groups (P = 0.016).
Mentions: There were 108 (32.4%) patients with blood group O, 140 (42.1%) with blood group A, 59 (17.7%) with blood group B, and 26 (7.8%) with blood group AB. The distribution of each blood group was similar to that of the general population in Japan.15 There were significantly more advanced-stage patients in blood group O than in any other group (P = 0.037). The overall survival curves of each blood group are shown in Figure 1. The five-year overall survival (OS) rate was 83.6% (95% CI, 75.0%–89.5%) for blood group O, 68.5% (95% CI, 59.8%–75.6%) for blood group A, 68.8% (95% CI, 55.2%–79.1%) for blood group B, and 69.2% (95% CI, 47.8%–83.3%) for blood group AB. The patients in blood group O showed significantly better survival than the patients in non-O blood groups (P = 0.016). Stratified analysis by p-stage revealed that the association between the ABO blood group and overall survival was similar in each p-stage group.

Bottom Line: The ABO blood group is reported to be associated with the incidence and patient survival for several types of malignancies.A multivariate analysis for overall survival showed the ABO blood group (group A vs. group O: HR 2.47, group AB vs. group O: HR 3.62) to be an independent significant prognostic factor, in addition to age, sex, smoking status, p-stage, and serum CEA level.A multivariate analysis for disease-free survival also showed the ABO blood group to be an independent significant prognostic factor.

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic Surgery, Nagoya University Graduate School of Medicine.

ABSTRACT

Background: The ABO blood group is reported to be associated with the incidence and patient survival for several types of malignancies. We conducted a retrospective study to evaluate the prognostic significance of the ABO blood group in patients with resected non-small cell lung cancer (NSCLC).

Methods: A total of 333 patients (218 men and 115 women) with resected NSCLC were included in this study. In addition to age, sex, smoking status, preoperative serum carcinoembryonic antigen (CEA) level, operative procedure, histology of tumors, pathological stage (p-stage), and adjuvant therapy, the association between the ABO blood group and survival was explored.

Results: The 5-year overall and disease-free survival rates were 83.0% and 71.6% for blood group O, 67.2% and 62.3% for blood group A, 68.8% and 68.8% for blood group B and 69.2% and 65.3% for blood group AB, respectively. A multivariate analysis for overall survival showed the ABO blood group (group A vs. group O: HR 2.47, group AB vs. group O: HR 3.62) to be an independent significant prognostic factor, in addition to age, sex, smoking status, p-stage, and serum CEA level. A multivariate analysis for disease-free survival also showed the ABO blood group to be an independent significant prognostic factor.

Conclusions: The ABO blood group is an independent prognostic factor in patients with resected NSCLC. Studies of other larger cohorts are therefore needed to confirm the relationship between the ABO blood group and the prognosis among patients with resected NSCLC.

Show MeSH
Related in: MedlinePlus