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Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.

Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ - Aging Cell (2014)

Bottom Line: We found that most sphingomyelin species increased with age.African Americans also showed higher circulating sphingomyelin concentrations compared to Caucasians.These results demonstrate that longitudinal changes in circulating sphingomyelin levels are influenced by age, sex, race, lifestyle factors, and diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Science Research and Neurology, Mayo Clinic, Rochester, MN, USA.

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Related in: MedlinePlus

Plasma sphingomyelins by age and sex. Concentrations are based on predicted values obtained in linear mixed models and controlling for additional factors specific to each model (see Table3).
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fig01: Plasma sphingomyelins by age and sex. Concentrations are based on predicted values obtained in linear mixed models and controlling for additional factors specific to each model (see Table3).

Mentions: We next identified factors associated cross-sectionally and longitudinally, in a time-dependent manner, with each of the sphingomyelin and dihydrosphingomyelin species using linear mixed models. We identified the most parsimonious models and determined the variables most strongly associated with each sphingomyelin class and individual species. Table3 and Fig.1 provide the model and model-fitted values for the sphingomyelins; Table4 and Fig.2 provide the model and model-fitted values for the dihydrosphingomyelins.


Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.

Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ - Aging Cell (2014)

Plasma sphingomyelins by age and sex. Concentrations are based on predicted values obtained in linear mixed models and controlling for additional factors specific to each model (see Table3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310757&req=5

fig01: Plasma sphingomyelins by age and sex. Concentrations are based on predicted values obtained in linear mixed models and controlling for additional factors specific to each model (see Table3).
Mentions: We next identified factors associated cross-sectionally and longitudinally, in a time-dependent manner, with each of the sphingomyelin and dihydrosphingomyelin species using linear mixed models. We identified the most parsimonious models and determined the variables most strongly associated with each sphingomyelin class and individual species. Table3 and Fig.1 provide the model and model-fitted values for the sphingomyelins; Table4 and Fig.2 provide the model and model-fitted values for the dihydrosphingomyelins.

Bottom Line: We found that most sphingomyelin species increased with age.African Americans also showed higher circulating sphingomyelin concentrations compared to Caucasians.These results demonstrate that longitudinal changes in circulating sphingomyelin levels are influenced by age, sex, race, lifestyle factors, and diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Science Research and Neurology, Mayo Clinic, Rochester, MN, USA.

Show MeSH
Related in: MedlinePlus