Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.
Bottom Line: We found that most sphingomyelin species increased with age.African Americans also showed higher circulating sphingomyelin concentrations compared to Caucasians.Notably, these associations showed specificity to sphingomyelin acyl-chain length and saturation.
Affiliation: Department of Health Science Research and Neurology, Mayo Clinic, Rochester, MN, USA.Show MeSH
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Mentions: We next identified factors associated cross-sectionally and longitudinally, in a time-dependent manner, with each of the sphingomyelin and dihydrosphingomyelin species using linear mixed models. We identified the most parsimonious models and determined the variables most strongly associated with each sphingomyelin class and individual species. Table3 and Fig.1 provide the model and model-fitted values for the sphingomyelins; Table4 and Fig.2 provide the model and model-fitted values for the dihydrosphingomyelins.
Affiliation: Department of Health Science Research and Neurology, Mayo Clinic, Rochester, MN, USA.