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Primary spindle cell sarcoma of the prostate and (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings.

Öztürk H - Urol Ann (2015 Jan-Mar)

Bottom Line: This type of cancer is associated with poor prognosis due to aggressive biological behavior.Average life expectancy is <1 year and the prognosis is poor.CTx and radiation therapy can't yield curative effects due to poor differentiation.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, School of Medicine, Sifa University, Izmir, Turkey.

ABSTRACT

Background: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. The World Health Organization histologically classified prostate sarcomas as stromal tumor of unknown malignant potential (STUMP) and stromal sarcoma.

Patients and methods: A 39-year-old patient presented with lower urinary tract symptoms over the last few months. On digital rectal examination, the right lobe of the prostate was diffusely hard on palpation. Prostate-specific antigen was 0.5 ng/ml. A biopsy specimen was obtained with the guidance of transrectal ultrasonography. Immunohistochemical examination revealed positive staining for vimentin, actin, and desmin.

Results: (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography scans obtained for staging purposes with the diagnosis of primary spindle cell carcinoma of the prostate revealed widespread lung and liver metastases. A doxorubicin-based systemic chemotherapy (CTx) was initiated.

Conclusion: Spindle sarcomas of the prostate have quite aggressive nature and they have high potential to metastase. Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can't yield curative effects due to poor differentiation.

No MeSH data available.


Related in: MedlinePlus

(a) The coronal 18F-fluorodeoxyglucose (18FDG)-positronemission tomography/computed tomography scans show, (blue arrow: Primary cancer, green arrow: Bladder FDG accumulation), SUVmax: 12.4, (b) maximum intensity projection images, (blue arrow: Primary cancer, green arrow: Bladder)
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Figure 1: (a) The coronal 18F-fluorodeoxyglucose (18FDG)-positronemission tomography/computed tomography scans show, (blue arrow: Primary cancer, green arrow: Bladder FDG accumulation), SUVmax: 12.4, (b) maximum intensity projection images, (blue arrow: Primary cancer, green arrow: Bladder)

Mentions: Late pelvic images of FDG-PET/CT revealed an activity of the primary tumor measuring 32 mm in diameter in the right lobe of the prostate with a standard uptake value (SUVmax) of 12.4 [Figure 1]. Metastatic lesions were observed, measuring 18 mm in the anterobasal lobe of the right lung (SUVmax: 8.1) and 26 mm in the right (SUVmax: 10.3) and 17 mm in the left lobe (SUVmax: 9.6) of the liver [Figure 2].


Primary spindle cell sarcoma of the prostate and (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography findings.

Öztürk H - Urol Ann (2015 Jan-Mar)

(a) The coronal 18F-fluorodeoxyglucose (18FDG)-positronemission tomography/computed tomography scans show, (blue arrow: Primary cancer, green arrow: Bladder FDG accumulation), SUVmax: 12.4, (b) maximum intensity projection images, (blue arrow: Primary cancer, green arrow: Bladder)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4310101&req=5

Figure 1: (a) The coronal 18F-fluorodeoxyglucose (18FDG)-positronemission tomography/computed tomography scans show, (blue arrow: Primary cancer, green arrow: Bladder FDG accumulation), SUVmax: 12.4, (b) maximum intensity projection images, (blue arrow: Primary cancer, green arrow: Bladder)
Mentions: Late pelvic images of FDG-PET/CT revealed an activity of the primary tumor measuring 32 mm in diameter in the right lobe of the prostate with a standard uptake value (SUVmax) of 12.4 [Figure 1]. Metastatic lesions were observed, measuring 18 mm in the anterobasal lobe of the right lung (SUVmax: 8.1) and 26 mm in the right (SUVmax: 10.3) and 17 mm in the left lobe (SUVmax: 9.6) of the liver [Figure 2].

Bottom Line: This type of cancer is associated with poor prognosis due to aggressive biological behavior.Average life expectancy is <1 year and the prognosis is poor.CTx and radiation therapy can't yield curative effects due to poor differentiation.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, School of Medicine, Sifa University, Izmir, Turkey.

ABSTRACT

Background: Primary sarcoma of the prostate is extremely rare and accounts for 0.1% of all prostate cancers. This type of cancer is associated with poor prognosis due to aggressive biological behavior. The World Health Organization histologically classified prostate sarcomas as stromal tumor of unknown malignant potential (STUMP) and stromal sarcoma.

Patients and methods: A 39-year-old patient presented with lower urinary tract symptoms over the last few months. On digital rectal examination, the right lobe of the prostate was diffusely hard on palpation. Prostate-specific antigen was 0.5 ng/ml. A biopsy specimen was obtained with the guidance of transrectal ultrasonography. Immunohistochemical examination revealed positive staining for vimentin, actin, and desmin.

Results: (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography scans obtained for staging purposes with the diagnosis of primary spindle cell carcinoma of the prostate revealed widespread lung and liver metastases. A doxorubicin-based systemic chemotherapy (CTx) was initiated.

Conclusion: Spindle sarcomas of the prostate have quite aggressive nature and they have high potential to metastase. Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can't yield curative effects due to poor differentiation.

No MeSH data available.


Related in: MedlinePlus