REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids.
Bottom Line: Moreover, REDD1 knockdown resulted in similar consequences in organotypic raft cultures of primary human keratinocytes.Importantly, the lack of REDD1 did not diminish the anti-inflammatory effects of glucocorticoids in preclinical model.Our findings suggest that combining steroids with REDD1 inhibitors may yield a novel, safer glucocorticoid-based therapies.
Affiliation: Department of Dermatology, Northwestern University, Chicago, IL, USA.Show MeSH
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Mentions: To assess the causative role of REDD1 in therapeutic and side effects of glucocorticoids in the skin, we compared REDD1 KO mice (Brafman et al, 2004) with isogenic controls (B6x129). REDD1 KO mice displayed mild epidermal hyperplasia and slightly increased keratinocyte proliferation (Fig3C and data not shown). There were no significant changes in early and medium/late differentiation markers including keratins K5, K10, loricrin, and involucrin (Supplementary Fig S2).
Affiliation: Department of Dermatology, Northwestern University, Chicago, IL, USA.