Structural associations of symptomatic knee osteoarthritis.
Bottom Line: In this study, we aimed to identify histopathologic features that are associated with symptomatic knee OA.To identify features of OA, we compared the patients with advanced OA with the age-matched non-OA controls (n = 26 per group).Synovitis, increased synovial NGF, alterations in chondrocyte morphology, and loss of cartilage integrity are features of knee OA that may be associated with symptoms.
Affiliation: Arthritis Research UK Pain Centre and University of Nottingham, Nottingham, UK.Show MeSH
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Mentions: NGF immunoreactivity in the synovium was predominantly localized to Hsp47+ spindle-shaped and mononuclear cells, consistent with fibroblast morphology (Figures 2A and B). However, some NGF+Hsp47– and NGF–Hsp47+ cells were also observed. Some CD68+macrophages in the lining and sublining regions also displayed NGF immunoreactivity (Figures 2C and D). Similar distributions were found in advanced OA patients and non-OA controls.
Affiliation: Arthritis Research UK Pain Centre and University of Nottingham, Nottingham, UK.