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Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy.

Moritoki Y, Kato T, Nishio H, Kamisawa H, Hirose Y, Ando R, Akita H, Okamura T - J Rural Med (2011)

Bottom Line: The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP).A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy.The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, J.A. Aichi Anjo Kosei Hospital, Japan.

ABSTRACT
A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

No MeSH data available.


Related in: MedlinePlus

Posttreatment CT shows less enhancement of a smaller soft tissue mass (30 × 18 × 36mm).
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fig_003: Posttreatment CT shows less enhancement of a smaller soft tissue mass (30 × 18 × 36mm).

Mentions: Salvage surgery was then considered for the residual mass because the superior vena cavawas still completely obstructed by the tumor. Although implantation of a prosthetic vesselwas required, the procedure was not performed because it was considered to be a high risksurgery. Instead, the patient received 2 courses of vinblastine, ifosfamide and cisplatin(VeIP) as salvage chemotherapy. On completion of the chemotherapy, the evaluable lesionswere considered to represent a "stable disease" (Figure3Figure 3


Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy.

Moritoki Y, Kato T, Nishio H, Kamisawa H, Hirose Y, Ando R, Akita H, Okamura T - J Rural Med (2011)

Posttreatment CT shows less enhancement of a smaller soft tissue mass (30 × 18 × 36mm).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4309346&req=5

fig_003: Posttreatment CT shows less enhancement of a smaller soft tissue mass (30 × 18 × 36mm).
Mentions: Salvage surgery was then considered for the residual mass because the superior vena cavawas still completely obstructed by the tumor. Although implantation of a prosthetic vesselwas required, the procedure was not performed because it was considered to be a high risksurgery. Instead, the patient received 2 courses of vinblastine, ifosfamide and cisplatin(VeIP) as salvage chemotherapy. On completion of the chemotherapy, the evaluable lesionswere considered to represent a "stable disease" (Figure3Figure 3

Bottom Line: The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP).A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy.The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, J.A. Aichi Anjo Kosei Hospital, Japan.

ABSTRACT
A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

No MeSH data available.


Related in: MedlinePlus