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Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy.

Moritoki Y, Kato T, Nishio H, Kamisawa H, Hirose Y, Ando R, Akita H, Okamura T - J Rural Med (2011)

Bottom Line: The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP).A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy.The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, J.A. Aichi Anjo Kosei Hospital, Japan.

ABSTRACT
A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

No MeSH data available.


Related in: MedlinePlus

Biopsy specimen from a right subclavicular lymph node. Well-defined tumor cells withlarge nuclei and clear nucleoli and a large clear reticulum are formed as map-likealveolar tumor cells. Cobblestone growth can be seen with lymph node involvementsurrounding the alveolar tissue.
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fig_002: Biopsy specimen from a right subclavicular lymph node. Well-defined tumor cells withlarge nuclei and clear nucleoli and a large clear reticulum are formed as map-likealveolar tumor cells. Cobblestone growth can be seen with lymph node involvementsurrounding the alveolar tissue.

Mentions: Pretreatment CT shows a solid soft tissue mass (95 × 75 × 112 mm) in the uppermediastinum, with leftward displacement of the trachea and complete obstruction of thesuperior vena cava.


Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy.

Moritoki Y, Kato T, Nishio H, Kamisawa H, Hirose Y, Ando R, Akita H, Okamura T - J Rural Med (2011)

Biopsy specimen from a right subclavicular lymph node. Well-defined tumor cells withlarge nuclei and clear nucleoli and a large clear reticulum are formed as map-likealveolar tumor cells. Cobblestone growth can be seen with lymph node involvementsurrounding the alveolar tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4309346&req=5

fig_002: Biopsy specimen from a right subclavicular lymph node. Well-defined tumor cells withlarge nuclei and clear nucleoli and a large clear reticulum are formed as map-likealveolar tumor cells. Cobblestone growth can be seen with lymph node involvementsurrounding the alveolar tissue.
Mentions: Pretreatment CT shows a solid soft tissue mass (95 × 75 × 112 mm) in the uppermediastinum, with leftward displacement of the trachea and complete obstruction of thesuperior vena cava.

Bottom Line: The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP).A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy.The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, J.A. Aichi Anjo Kosei Hospital, Japan.

ABSTRACT
A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.

No MeSH data available.


Related in: MedlinePlus