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The use of a dehydrated amnion/chorion membrane allograft in patients who subsequently undergo reexploration after posterior lumbar instrumentation.

Subach BR, Copay AG - Adv Orthop (2015)

Bottom Line: Conclusions.Our findings suggest that dHACM implant during TLIF may have favorable effects on epidural fibrosis and is well tolerated.Further studies with larger cohorts are required to prove our results.

View Article: PubMed Central - PubMed

Affiliation: Virginia Spine Institute & Spinal Research Foundation, 1831 Wiehle Avenue, Suite 200, Reston, VA 20190, USA.

ABSTRACT
Background Context. Products that can reduce development of epidural fibrosis may reduce risk for ongoing pain associated with development of scar tissue and make subsequent epidural reexploration easier. Purpose. To evaluate the use of dehydrated human amnion/chorion membrane (dHACM) on the formation of soft tissue scarring in the epidural space. Study Design. Case series. Patient Sample. Five patients having transforaminal lumbar interbody lumbar fusion (TLIF) with posterior instrumentation and implantation of dHACM in the epidural space and subsequent epidural reexploration. Outcome Measures. Degree of scar tissue adjacent to the epidural space at reexploration. Intraoperative and postoperative complications related to dHACM and patient reported outcomes. Methods. The degree of scar tissue adjacent to the epidural space was assessed during the reexploration surgery. Patients' outcomes were collected using standard validated questionnaires. Results. Four of 5 cases had easily detachable tissue during epidural reexploration. Angiolipoma of 10% was noted in 1 case and 5% in 2 cases. Significant improvements in patient reported outcomes were observed. No intraoperative or postoperative complications occurred. Conclusions. Our findings suggest that dHACM implant during TLIF may have favorable effects on epidural fibrosis and is well tolerated. Further studies with larger cohorts are required to prove our results.

No MeSH data available.


Related in: MedlinePlus

Histologic overview (H & E, original magnification ×100 or ×40).
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fig1: Histologic overview (H & E, original magnification ×100 or ×40).

Mentions: During the study period a total of 5 patients (males, average age 61 years) without history of prior spinal surgery underwent TLIF with dHACM and subsequent reexploration. Patient diagnosis, levels of TLIF, adhesion score assessed at reexploration, and histological analysis of fibrosis and fat infiltration are reported in Table 2. Four of 5 cases had easily detachable tissue during instrumentation removal. The histological analysis showed minimal fibrosis and fat infiltration in most cases (Table 2 and Figure 1).


The use of a dehydrated amnion/chorion membrane allograft in patients who subsequently undergo reexploration after posterior lumbar instrumentation.

Subach BR, Copay AG - Adv Orthop (2015)

Histologic overview (H & E, original magnification ×100 or ×40).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4309213&req=5

fig1: Histologic overview (H & E, original magnification ×100 or ×40).
Mentions: During the study period a total of 5 patients (males, average age 61 years) without history of prior spinal surgery underwent TLIF with dHACM and subsequent reexploration. Patient diagnosis, levels of TLIF, adhesion score assessed at reexploration, and histological analysis of fibrosis and fat infiltration are reported in Table 2. Four of 5 cases had easily detachable tissue during instrumentation removal. The histological analysis showed minimal fibrosis and fat infiltration in most cases (Table 2 and Figure 1).

Bottom Line: Conclusions.Our findings suggest that dHACM implant during TLIF may have favorable effects on epidural fibrosis and is well tolerated.Further studies with larger cohorts are required to prove our results.

View Article: PubMed Central - PubMed

Affiliation: Virginia Spine Institute & Spinal Research Foundation, 1831 Wiehle Avenue, Suite 200, Reston, VA 20190, USA.

ABSTRACT
Background Context. Products that can reduce development of epidural fibrosis may reduce risk for ongoing pain associated with development of scar tissue and make subsequent epidural reexploration easier. Purpose. To evaluate the use of dehydrated human amnion/chorion membrane (dHACM) on the formation of soft tissue scarring in the epidural space. Study Design. Case series. Patient Sample. Five patients having transforaminal lumbar interbody lumbar fusion (TLIF) with posterior instrumentation and implantation of dHACM in the epidural space and subsequent epidural reexploration. Outcome Measures. Degree of scar tissue adjacent to the epidural space at reexploration. Intraoperative and postoperative complications related to dHACM and patient reported outcomes. Methods. The degree of scar tissue adjacent to the epidural space was assessed during the reexploration surgery. Patients' outcomes were collected using standard validated questionnaires. Results. Four of 5 cases had easily detachable tissue during epidural reexploration. Angiolipoma of 10% was noted in 1 case and 5% in 2 cases. Significant improvements in patient reported outcomes were observed. No intraoperative or postoperative complications occurred. Conclusions. Our findings suggest that dHACM implant during TLIF may have favorable effects on epidural fibrosis and is well tolerated. Further studies with larger cohorts are required to prove our results.

No MeSH data available.


Related in: MedlinePlus